JBJ-04-125-02

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Products Intro: Product Name:JBJ-04-125-02
CAS:2060610-53-7
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:2060610-53-7
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CAS:2060610-53-7
Purity:98% Package:25mg Remarks:V37821
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Products Intro: Product Name:JBJ-04-125-02
CAS:2060610-53-7
Package:100mg;4400USD|50mg;3480USD|25mg;2820USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:JBJ-04-125-02
CAS:2060610-53-7
Package:100mg;2500USD|50mg;1980USD|25mg;1520USD

JBJ-04-125-02 manufacturers

  • JBJ-04-125-02
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  • $4400.00
  • 2026-05-22
  • CAS:2060610-53-7
  • Purity:
  • Supply Ability: 10g
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  • $4400.00
  • 2026-05-21
  • CAS:2060610-53-7
  • Purity:
  • Supply Ability: 10g
  • JBJ-04-125-02
  • JBJ-04-125-02 pictures
  • $2500.00
  • 2025-08-22
  • CAS:2060610-53-7
  • Purity:
  • Supply Ability: 10g
JBJ-04-125-02 Basic information
Product Name:JBJ-04-125-02
Synonyms:JBJ-04-125-02 R-isomer;2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-6-[4-(1-piperazinyl)phenyl]-N-2-thiazolyl-, (αR)-;JBJ0412502,JBJ 04 125 02;(R)-2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide;(2R)-2-(5-Fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide
CAS:2060610-53-7
MF:C29H26FN5O3S
MW:543.62
EINECS:
Product Categories:
Mol File:2060610-53-7.mol
JBJ-04-125-02 Structure
JBJ-04-125-02 Chemical Properties
density 1.424±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka7.24±0.50(Predicted)
Safety Information
MSDS Information
JBJ-04-125-02 Usage And Synthesis
UsesJBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities[1].
in vivo

JBJ-04-125-02 (50 mg/kg; oral gavage; once daily; for 15 weeks; EGFRL858R/T790M/C797S genetically engineered mice) treatment leads to marked tumor regressions within 4 weeks of treatment[1].
JBJ-04-125-02 exhibits a moderate half-life of 3 hours and a high area under curve of 728,577 minng/mL (AUClast) following 3 mg/kg intravenous (i.v.) dose. A 20 mg/kg oral dose of JBJ-04-125-02 achieves an average maximal plasma concentration of 1.1 μmol/L with an oral bioavailability of 3%[1].

Animal Model:EGFRL858R/T790M/C797S genetically engineered mice (GEM)[1]
Dosage:50 mg/kg
Administration:Oral gavage; once daily; for 15 weeks
Result:Led to marked tumor regressions within 4 weeks of treatment.
IC 50EGFR (L858R/T790M): 0.26 nM (IC50)
References[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943. DOI:10.1158/2159-8290.CD-18-0903
JBJ-04-125-02 Preparation Products And Raw materials
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