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| | trans-2-Benzylamino-1-cyclohexanol Basic information |
| Product Name: | trans-2-Benzylamino-1-cyclohexanol | | Synonyms: | TRANS-2-BENZYLAMINO-1-CYCLOHEXANOL;TRANS-2-(BENZYLAMINO)CYCLOHEXANOL;Trans-2-benzylamino-1-cyclohexanol, 99+%;(1R,2R)-2-(benzylamino)cyclohexanol;(1R,2R)-2-(benzylaMino)cyclopentanol;rel-(1R,2R)-2-[(Phenylmethyl)amino]cyclohexanol;(2-hydroxycyclohexyl)-(phenylmethyl)ammonium;amino)cycL | | CAS: | 40571-86-6 | | MF: | C13H19NO | | MW: | 205.3 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 40571-86-6.mol |  |
| | trans-2-Benzylamino-1-cyclohexanol Chemical Properties |
| Melting point | 69-72 °C | | Boiling point | 69-72°C | | density | 0.9923 (rough estimate) | | refractive index | 1.5175 (estimate) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 14.83±0.40(Predicted) | | form | crystal | | color | white |
| | trans-2-Benzylamino-1-cyclohexanol Usage And Synthesis |
| Chemical Properties | VERY SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER | | Uses | suzuki reaction | | Synthesis | General procedure for the synthesis of trans-2-benzylaminocyclohexanol from cyclohexene oxide and benzylamine: cyclohexene oxide (20 g, 204 mmol) was mixed with benzylamine (44 g, 411 mmol), and the reaction was carried out for 6 hours at 80 °C. After completion of the reaction, the excess benzylamine was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a chloroform solution of 5-10% methanol to give (1RS,2RS)-trans-2-benzylaminocyclohexanol (26 g, 127 mmol, 62% yield) as white crystals. | | References | [1] Tetrahedron Letters, 2008, vol. 49, # 9, p. 1546 - 1550
[2] Tetrahedron, 2011, vol. 67, # 47, p. 9214 - 9218
[3] Journal of Organic Chemistry, 2007, vol. 72, # 10, p. 3713 - 3722
[4] Tetrahedron Letters, 1990, vol. 31, # 32, p. 4661 - 4664
[5] Synthetic Communications, 2001, vol. 31, # 21, p. 3295 - 3302 |
| | trans-2-Benzylamino-1-cyclohexanol Preparation Products And Raw materials |
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