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| | 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE Basic information | | Uses |
| Product Name: | 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE | | Synonyms: | 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE;4-AMINO-ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)BENZYL ALCOHOL;2-(4-AMINOPHENYL)HEXAFLUORO-2-PROPANOL;4-amino-à-à-bis(trifluoromethyl)benzyl alcohol;4-(Hexafluoro-2-hydroxyisopropyl)aniline 97%;4-(Hexafluoro-2-hydroxyisopropyl)aniline97%;2-(4-AMINO-PHENYL)-1,1,1,3,3,3-HEXAFLUORO-PROPAN-2-OL;2-(4-Aminophenyl) hexafluoropropan-ol | | CAS: | 722-92-9 | | MF: | C9H7F6NO | | MW: | 259.15 | | EINECS: | | | Product Categories: | | | Mol File: | 722-92-9.mol |  |
| | 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE Chemical Properties |
| Melting point | 147-152 °C | | Boiling point | 292.9±40.0 °C(Predicted) | | density | 1.505±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 9.86±0.15(Predicted) | | form | Crystalline Powder | | color | Light brown | | BRN | 1473737 | | InChI | InChI=1S/C9H7F6NO/c10-8(11,12)7(17,9(13,14)15)5-1-3-6(16)4-2-5/h1-4,17H,16H2 | | InChIKey | TZEJXCIGVMTMDY-UHFFFAOYSA-N | | SMILES | C(O)(C(F)(F)F)(C(F)(F)F)C1C=CC(N)=CC=1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | RIDADR | 2811 | | Hazard Note | Irritant/Keep Cold under Argon | | HazardClass | IRRITANT | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29221990 |
| | 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE Usage And Synthesis |
| Uses | 2-(4-aminobenzene)-1,1,1,3,3,3-hexafluoro-2-propanol can be used to prepare bisphenol AF. Bisphenol AF (hexafluorobisphenol A: 2,2-bis-(4-hydroxyphenyl)hexafluoropropane) is mainly used as a vulcanization accelerator for fluororubber. | | Chemical Properties | Light brown crystalline powder | | Synthesis | To a xylene solution of aniline (7, 21.47 mmol) and p-toluenesulfonic acid (pTSA, 1.28 mmol) was added hexafluoroacetone trihydrate (8, 64.42 mmol) and the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, it was cooled to room temperature to allow the product 4-(hexafluoro-2-hydroxyisopropyl)aniline (9) to crystallize and precipitate, which was collected by filtration and used directly in the next step of the reaction. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1638 - 1642
[2] European Journal of Medicinal Chemistry, 2016, vol. 122, p. 744 - 755
[3] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990, vol. 39, # 2.2, p. 323 - 328
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990, # 2, p. 383 - 389
[5] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990, vol. 39, # 2.2, p. 323 - 328 |
| | 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE Preparation Products And Raw materials |
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