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| | 4-METHOXYPICOLINALDEHYDE Basic information |
| Product Name: | 4-METHOXYPICOLINALDEHYDE | | Synonyms: | 4-METHOXYPICOLINALDEHYDE;2-Formyl-4-methoxypyridine, 4-Methoxypicolinaldehyde;2-Pyridinecarboxaldehyde,4-methoxy-;4-Methoxypyridine-2-carboxaldehyde;4-Methoxypyridine-2-carbaldehyde;4-Methoxy-2-forMylpyridine;4-Methoxy-2-Pyridinecarboxaldehyde;4-Methoxy-2-pyridinecarbaldehyde | | CAS: | 16744-81-3 | | MF: | C7H7NO2 | | MW: | 137.14 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 16744-81-3.mol |  |
| | 4-METHOXYPICOLINALDEHYDE Chemical Properties |
| Melting point | 28-30℃ | | Boiling point | 125-130℃ (25 Torr) | | density | 1.159±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.47±0.10(Predicted) | | Appearance | White to yellow Solid-liquid mixture |
| RIDADR | UN2811 | | HS Code | 2933399990 |
| | 4-METHOXYPICOLINALDEHYDE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 4-methoxypyridin-2-aldehyde from (4-methoxypyridin-2-yl)methanol was as follows:
- Manganese(IV) oxide (2.412 mL, 139.42 mmol, 4 eq.) was added batchwise to a solution of (4-methoxypyridin-2-yl)methanol (4.85 g, 34.85 mmol, 1 eq.) in ethyl acetate (150 mL).
- The reaction mixture was stirred at 80 °C for 2 hours.
- Upon completion of the reaction, the hot reaction mixture was filtered through diatomaceous earth.
- The filtrate was evaporated to dryness to afford the target product 4-methoxypyridine-2-aldehyde (3.01 g, 21.93 mmol, 62.9% yield).
1H NMR (400.132 MHz, DMSO) δ 3.93 (3H, s), 7.27 (1H, m), 7.44 (1H, d), 8.63 (1H, d), 9.96 (1H, s). | | References | [1] Patent: WO2009/56886, 2009, A1. Location in patent: Page/Page column 54
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Inorganic Chemistry, 2013, vol. 52, # 11, p. 6481 - 6501
[4] Bulletin of the Chemical Society of Japan, 2015, vol. 88, # 6, p. 784 - 791
[5] Yakugaku Zasshi, 1957, vol. 77, p. 11,13 |
| | 4-METHOXYPICOLINALDEHYDE Preparation Products And Raw materials |
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