- 4-Hydroxy-6,7-dimethoxyquinoline
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- $200.00 / 1KG
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2025-09-25
- CAS:13425-93-9
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 4-Hydroxy-6,7-dimethoxyqunioline Basic information | | Appearance |
| Product Name: | 4-Hydroxy-6,7-dimethoxyqunioline | | Synonyms: | 6,7-Dimethoxy-4-hydroxyquinoline;4-hydroxy-(6,7-dimethoxyqunioine;6,7-DIMETHOXYQUINOLIN-4(1H)-ONE;4-HYDROXY-6,7-DIMETHOXYQUINOLINE;4-HYDROXY-6,7-DIMETHOXYQUNIOLINE;6,7-Dimethoxy-quinolin-4-ol;4-Quinolinol,6,7-diMethoxy-;6,7-DIMETHOXYQUINOLINE-4-OL | | CAS: | 13425-93-9 | | MF: | C11H11NO3 | | MW: | 205.21 | | EINECS: | 811-007-0 | | Product Categories: | Quinoline series;Heterocycles | | Mol File: | 13425-93-9.mol |  |
| | 4-Hydroxy-6,7-dimethoxyqunioline Chemical Properties |
| Melting point | 227.0 to 231.0 °C | | Boiling point | 370.9±37.0 °C(Predicted) | | density | 1.257±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | powder to crystal | | pka | 4.26±0.40(Predicted) | | color | Light orange to Yellow to Green | | InChI | InChI=1S/C11H11NO3/c1-14-10-5-7-8(6-11(10)15-2)12-4-3-9(7)13/h3-6H,1-2H3,(H,12,13) | | InChIKey | QOGPNCUTXVZQSL-UHFFFAOYSA-N | | SMILES | N1C2C(=CC(OC)=C(OC)C=2)C(O)=CC=1 | | CAS DataBase Reference | 13425-93-9(CAS DataBase Reference) |
| HS Code | 2933.49.7000 | | HazardClass | IRRITANT |
| | 4-Hydroxy-6,7-dimethoxyqunioline Usage And Synthesis |
| Appearance | 4-Hydroxy-6,7-dimethoxyqunioline is a slightly pale yellow to yellow solid. | | Uses | 4-Hydroxy-6,7-dimethoxyqunioline, also called 6,7-Dimethoxy-4-quinolinol was used in the study of synthesis of ring-substituted 4-aminoquinolines and evaluation fo their antimalarial activities. | | Synthesis | General procedure for the synthesis of 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate: ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate (700 mg, 2.53 mmol) was added to potassium hydroxide (450 mg, 7.6 mmol) dissolved in 20 mL of H2O/EtOH (1:1, v /v) solution. The mixture was placed in a sealed container (XP-500 Plus container) and heated using microwaves (MARS 5 Microwave System) at 180°C, 260-280 psi pressure for 50 min. Upon completion of the reaction, the mixture was cooled to room temperature and transferred to a flask. Subsequently, the solution was acidified to pH about 6 with acetic acid (about 2 mL), saturated with sodium chloride, and extracted with tetrahydrofuran (3 x 100 mL). The organic layers were combined, washed with brine and concentrated to give 6,7-dimethoxyquinolin-4-ol in 90% yield.1H NMR (400 MHz, DMSO-d6) δ ppm: 3.81 (s, 3H), 3.84 (s, 3H), 5.93 (d, J=7.3 Hz, 1H), 7.05 (s, 1H), 7.42 (s, 1H), and 7.76 (d, J=7.3 Hz, 1H). | | storage | Store at room temperature. | | References | [1] Patent: WO2005/121125, 2005, A1. Location in patent: Page/Page column 41-42
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1264 |
| | 4-Hydroxy-6,7-dimethoxyqunioline Preparation Products And Raw materials |
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