- 6-Chloronicotinic acid
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- $10.00 / 1KG
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2026-03-06
- CAS:5326-23-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- 6-Chloronicotinic acid
-
- $8.00 / 1KG
-
2025-09-25
- CAS:5326-23-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 6-Chloronicotinic Acid
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- $10.70 / 1kg
-
2025-05-26
- CAS:5326-23-8
- Min. Order: 10kg
- Purity: 99%
- Supply Ability: 10000kg
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| | 6-Chloronicotinic acid Basic information |
| | 6-Chloronicotinic acid Chemical Properties |
| Melting point | 190 °C (dec.)(lit.) | | Boiling point | 241.15°C (rough estimate) | | density | 0.5 | | refractive index | 1.5870 (estimate) | | Fp | 192°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | deionized water: soluble | | form | Crystalline Powder | | pka | 3.24±0.10(Predicted) | | color | Off-white to beige | | Water Solubility | Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform. | | Decomposition | 192 ºC | | BRN | 115993 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | 1S/C6H4ClNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H,9,10) | | InChIKey | UAWMVMPAYRWUFX-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccc(Cl)nc1 | | CAS DataBase Reference | 5326-23-8(CAS DataBase Reference) | | NIST Chemistry Reference | 6-Chloronicotinic acid(5326-23-8) | | EPA Substance Registry System | 6-Chloronicotinic acid (5326-23-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25-37/39 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 6-Chloronicotinic acid Usage And Synthesis |
| Chemical Properties | Off-white to beige crystalline powder | | Uses | 6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors. | | Uses | 6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples. | | Definition | ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid. | | General Description | 6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management. | | Synthesis |
In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.
| | Purification Methods | Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.] |
| | 6-Chloronicotinic acid Preparation Products And Raw materials |
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