- 3,5-Diaminobenzoic acid
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- $36.28
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2026-08-21
- CAS:535-87-5
- Min. Order: 25Kg/Drum
- Purity: 99.50%HPLC
- Supply Ability: 10tons/month
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| | 3,5-Diaminobenzoic acid Basic information |
| Product Name: | 3,5-Diaminobenzoic acid | | Synonyms: | DiaMinobenzoic aci;5-Carboxybenzene-1,3-diamine, 5-Carboxyphenylene-1,3-diamine;3,5- twoaMinobenzoic acid;3, 5-2 aMino acid;3,5-DiaMinoben;3,5-DIAMINOBENZOIC ACID;3,5-Diaminobenzoic acid,98%;3,5-Diaminobenzoic a | | CAS: | 535-87-5 | | MF: | C7H8N2O2 | | MW: | 152.15 | | EINECS: | 208-621-0 | | Product Categories: | Aromatic Amino AcidsFluorescent Probes, Labels, Particles and Stains;Fluorescent Labels;Other Fluorescent Labels;Peptide Synthesis;Organic acids;Unnatural Amino Acid Derivatives;535-87-5 | | Mol File: | 535-87-5.mol |  |
| | 3,5-Diaminobenzoic acid Chemical Properties |
| Melting point | 235-238 °C (dec.) (lit.) | | Boiling point | 274.61°C (rough estimate) | | density | 1.2804 (rough estimate) | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.5200 (estimate) | | Fp | 235-240°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Sparingly), Methanol (Slightly) | | form | Powder | | pka | pK1:5.30 (25°C) | | color | White to gray | | Water Solubility | Very soluble in water. | | Decomposition | 235-240 ºC | | Merck | 14,2978 | | BRN | 2086484 | | InChI | 1S/C7H8N2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,8-9H2,(H,10,11) | | InChIKey | UENRXLSRMCSUSN-UHFFFAOYSA-N | | SMILES | Nc1cc(N)cc(c1)C(O)=O | | LogP | -0.51 | | CAS DataBase Reference | 535-87-5(CAS DataBase Reference) | | EPA Substance Registry System | Benzoic acid, 3,5-diamino- (535-87-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | DG6186000 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HS Code | 29224995 | | Storage Class | 11 - Combustible Solids |
| | 3,5-Diaminobenzoic acid Usage And Synthesis |
| Chemical Properties | White to grey powder | | Uses | 3,5-diaminobenzoic acid be used as organic intermediates. | | Uses | 3,5-Diaminobenzoic acid is an analog of diatriazoate, which has been shown to have antigenicity properties towards the monoclonal antibodies. It is used as pharmaceutical intermediate. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | General procedure for the synthesis of 3,5-diaminobenzoic acid from 3,5-dinitrobenzoic acid: 3,5-dinitrobenzoic acid (51 g, 0.24 mol) and 300 mL of water were added to a 1 L stainless steel high-pressure reactor and stirred thoroughly until homogeneous. Subsequently, the pH of the reaction system was adjusted to 7-8 using an aqueous sodium hydroxide solution with a mass percent concentration of 20%. 0.25 g of Ni-Yb-Al triple-acting catalyst was added followed by three nitrogen substitutions to remove air. The hydrogen pressure was controlled at 0.2 MPa and the reaction temperature was maintained at 25-30 °C until the reaction pressure decreased significantly, indicating the completion of the reaction. Upon completion of the reaction, the catalyst was recovered by filtration. The filtrate was adjusted to pH 3 with concentrated hydrochloric acid to precipitate the target product 3,5-diaminobenzoic acid. The solid product was collected by filtration, washed with water and finally dried under vacuum to give 36.5 g of 3,5-diaminobenzoic acid in 98.8% yield and 98.9% HPLC purity. The retention time of the product was consistent with the standard control. | | Purification Methods | Crystallise the acid from water. The dihydrochloride has m 226-228o(dec). [Beilstein 14 H 453, 14 III 1179, 14 IV 1304.] | | References | [1] Patent: CN105949076, 2016, A. Location in patent: Paragraph 0025; 0026; 0031; 0036; 0040; 0045; 0053
[2] Journal of the Iranian Chemical Society, 2014, vol. 11, # 6, p. 1587 - 1592
[3] Synthetic Communications, 2000, vol. 30, # 20, p. 3639 - 3644
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 9, p. 709 - 711
[5] Synthetic Communications, 2003, vol. 33, # 2, p. 281 - 289 |
| | 3,5-Diaminobenzoic acid Preparation Products And Raw materials |
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