- Dihydrofuran-3(2H)-one
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- $0.00 / 1KG
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2026-01-07
- CAS:22929-52-8
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
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| | Dihydrofuran-3(2H)-one Basic information |
| | Dihydrofuran-3(2H)-one Chemical Properties |
| Boiling point | 68°C/60mmHg(lit.) | | density | 1.1124 g/cm3(Temp: 420 °C) | | refractive index | 1.4360-1.4400 | | Fp | 56°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Liquid | | color | Colorless to Yellow | | Stability: | Volatile | | InChI | InChI=1S/C4H6O2/c5-4-1-2-6-3-4/h1-3H2 | | InChIKey | JLPJFSCQKHRSQR-UHFFFAOYSA-N | | SMILES | O1CCC(=O)C1 |
| | Dihydrofuran-3(2H)-one Usage And Synthesis |
| Chemical Properties | Colorless transparent liquid | | Uses | 3-Oxotetrahydrofuran is a reagent in the preperation of dihydropteridinone which are orally active Polo-like kinase-2 (Plk-2) inhibitors. | | Definition | ChEBI: Oxolan-3-one is an oxalane substituted by an oxo group at position 3. It is functionally related to an oxolane. | | Synthesis | The general procedure for the synthesis of dihydro-3(2H)-furanone from 3-hydroxytetrahydrofuran was as follows: 3-hydroxytetrahydrofuran (3-OH-THF, 60.6 g, 0.68 mol, 1.0 eq.) was added to a 1 L three-necked flask, followed by the addition of dichloromethane (DCM, 620 mL) and 2,2,6,6-tetramethylpiperidin-1-oxyl radical (TEMPO 1.08 g, 0.0069 mol, 0.01 equiv). The reaction system was cooled to -5°C. Trichloroisocyanuric acid (TCCA, 159.6 g, 0.68 mol, 1.0 eq.) was added in batches while maintaining the temperature at -5°C to 0°C. The reaction mixture was gradually warmed up to room temperature and the reaction progress was monitored by gas chromatography-mass spectrometry (GC-MS). The reaction was completed after about 1 h. The product yield was 95% by GC area percentage analysis. | | References | [1] Patent: WO2014/139080, 2014, A1. Location in patent: Page/Page column 8; 9
[2] Patent: WO2014/140017, 2014, A1. Location in patent: Page/Page column 7
[3] Patent: US2014/275579, 2014, A1. Location in patent: Paragraph 0033
[4] Patent: WO2006/67430, 2006, A1. Location in patent: Page/Page column 50
[5] Patent: WO2018/132905, 2018, A1. Location in patent: Paragraph 00420-00422 |
| | Dihydrofuran-3(2H)-one Preparation Products And Raw materials |
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