- Methyl carbazate
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2026-07-02
- CAS:6294-89-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20ton
- Methyl Carbazate
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2026-06-15
- CAS:6294-89-9
- Min. Order: 1Kg
- Purity: ≥98%
- Supply Ability: 10 tons
- Methyl carbazate
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- $5.00
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2026-05-28
- CAS:6294-89-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
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| | Methyl carbazate Basic information |
| | Methyl carbazate Chemical Properties |
| Hazard Codes | Xi,T | | Risk Statements | 36/37/38-48-23/25-25 | | Safety Statements | 26-37/39-45-38-36/37/39-22-36/37 | | RIDADR | 2811 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29280000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Methyl carbazate Usage And Synthesis |
| Chemical Properties | WHITE TO PINK CRYSTALLINE PLATELETS | | Uses | Hydrazine derivative. | | Uses | Methyl carbazate was used in the preparation of methyl 3-(4-methyl-benzyl-idene)carbazate. It was also used in the synthesis of imidazo[1,5-d][1,2,4]triazines. It is used as pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of methyl hydrazinecarboxylate from dimethyl carbonate: Dimethyl carbonate (1, 45.0 g, 0.50 mol) and hydrazine hydrate (29.4 mL, 0.48 mol) were added to a 250 mL round-bottomed flask and the unit was equipped with a condenser. The reaction mixture was heated to 50°C with continuous stirring for 30 minutes, followed by continued stirring at room temperature for 24 hours. After completion of the reaction, water, methanol and excess dimethyl carbonate were removed by distillation under reduced pressure. The product was dried to give white crystals of methyl hydrazinecarboxylate (2, 42.3 g) in 94% yield with a melting point of 69-70°C. The 1H NMR (300 MHz, CDCl3) data were as follows: δ 3.73 (s, 3H, CH3-O), 3.77 (d, 2H, J = 1.85 Hz, -NH2), 6.09 (s, 1H, -NH). | | Purification Methods | To remove impurities, the material is melted and pumped under vacuum until the vapours are spectroscopically pure [Caminati et al. J Am Chem Soc 108 4364 1986]. Distil it in a vacuum. [Beilstein 3 I 46.] | | References | [1] Journal of Agricultural and Food Chemistry, 2009, vol. 57, # 10, p. 4279 - 4286
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 31, p. 8172 - 8175
[3] Angew. Chem., 2014, vol. 126, # 31, p. 8311 - 8314,4
[4] Chinese Chemical Letters, 2017, vol. 28, # 2, p. 372 - 376
[5] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1238 - 1242 |
| | Methyl carbazate Preparation Products And Raw materials |
| Raw materials | Dimethyl carbonate | | Preparation Products | Ethyl carbazate-->METHYL HYDRAZODICARBOXYLATE-->METHYL 2-(1-METHYL-3-PHENYL-2-PROPENYLIDENE)-1-HYDRAZINECARBOXYLATE-->4-(2-Chlorophenyl)-1,2,3-thiadiazole-5-carbonitrile-->Hydrazinecarboxylic acid, 2-(phenylmethylene)-, methyl ester-->Hydrazinecarboxylic acid, 2-[1-(4-methoxyphenyl)ethylidene]-, methyl ester-->ETHYL (3E)-3-(ACETYLHYDRAZONO)-2-CHLOROBUTANOATE-->Anthracene-2-carboxylic acid methyl ester-->4-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one-->4-(3-Chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one |
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