D-MANNOHEPTULOSE manufacturers
- D-Mannoheptulose
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- $0.00 / 10G
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2026-04-10
- CAS:3615-44-9
- Min. Order: 10G
- Purity: 98%min
- Supply Ability: 30kg/month
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| | D-MANNOHEPTULOSE Basic information |
| | D-MANNOHEPTULOSE Chemical Properties |
| Melting point | 148-150°C | | alpha | D20 +29° (c = 2 in H2O) | | Boiling point | 628.0±55.0 °C(Predicted) | | density | 1.645±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Methanol (Slightly), Water (Slightly) | | pka | 11.86±0.20(Predicted) | | form | Solid | | color | White to Off-White | | Optical Rotation | +29 | | Merck | 13,4686 | | BRN | 1726433 | | InChI | 1S/C7H14O7/c8-1-3-4(10)5(11)6(12)7(13,2-9)14-3/h3-6,8-13H,1-2H2/t3-,4-,5+,6+,7/m1/s1 | | InChIKey | HAIWUXASLYEWLM-BWSJPXOBSA-N | | SMILES | OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H](O)[C@@H]1O | | EPA Substance Registry System | D-manno-2-Heptulose (3615-44-9) |
| Safety Statements | 24/25 | | WGK Germany | 2 | | TSCA | TSCA listed | | HS Code | 29400090 | | Storage Class | 11 - Combustible Solids |
| | D-MANNOHEPTULOSE Usage And Synthesis |
| Description | D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose. | | Chemical Properties | White Solid | | Uses | Mannoheptulose occurs naturally in avocado fruit. It is used for normalizing insulin levels and reducing weight. | | Definition | ChEBI: D-keto-manno-heptulose is the open chain form of D-manno-heptulose. | | References | [1] H G COORE P J R. Inhibition of glucose phosphorylation by mannoheptulose.[J]. Biochemical Journal, 1964, 91 1: 56-59. DOI: 10.1042/bj0910056
[2] S J ASHCROFT P J R. Enzymes of glucose metabolism in normal mouse pancreatic islets.[J]. Biochemical Journal, 1970, 119 1: 5-15. DOI: 10.1042/bj1190005
[3] N DAI. Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence.[J]. Plant Cell, 1999, 11 7: 1253-1266. DOI: 10.1105/tpc.11.7.1253
[4] S J ASHCROFT P J R L C Weerasinghe. Interrelationship of islet metabolism, adenosine triphosphate content and insulin release.[J]. Biochemical Journal, 1973, 132 2: 223-231. DOI: 10.1042/bj1320223
[5] DANIEL JOHNSON. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.[J]. Diabetes, 2007, 56 6: 1694-1702. DOI: 10.2337/db07-0026
[6] MING V. LI . Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)[J]. Biochemical and biophysical research communications, 2010, 395 3: Pages 395-400. DOI: 10.1016/j.bbrc.2010.04.028
[7] LESLIE L MCKNIGHT. Mannoheptulose has differential effects on fasting and postprandial energy expenditure and respiratory quotient in adult Beagle dogs fed diets of different macronutrient contents.[J]. Journal of Nutritional Science, 2014, 3: e17. DOI: 10.1017/jns.2014.17 |
| | D-MANNOHEPTULOSE Preparation Products And Raw materials |
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