- 3,5-Difluoropyridine
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- $1.10
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2025-06-25
- CAS:71902-33-5
- Min. Order: 1g
- Purity: 99.0% min
- Supply Ability: 100 tons min
- 3,5-Difluoropyridine
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- $3.00
-
2019-07-06
- CAS:71902-33-5
- Min. Order: 1KG
- Purity: 90%-99.9%
- Supply Ability: 500kg
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| | 3,5-Difluoropyridine Basic information | | Synthesis |
| Product Name: | 3,5-Difluoropyridine | | Synonyms: | 3,5-DIFLUOROPYRIDINE;3,5-Difluoropyridine 98%;3,5-Difluoropyridine98%;3,5-Difluropyridine;3,5-Difluoropyridine>;Pyridine, 3,5-difluoro-;3,5-Difluoropyridine ISO 9001：2015 REACH | | CAS: | 71902-33-5 | | MF: | C5H3F2N | | MW: | 115.08 | | EINECS: | 624-636-9 | | Product Categories: | Fluorine series;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridine;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building BlocksHeterocyclic Building Blocks;New Products for Chemical Synthesis;Fluorin-contained pyridine series | | Mol File: | 71902-33-5.mol |  |
| | 3,5-Difluoropyridine Chemical Properties |
| Boiling point | 92-93°C | | density | 1.256 g/mL at 25 °C | | refractive index | 1.4437 | | Fp | 9°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | pka | 0.39±0.20(Predicted) | | color | Colorless to Almost colorless | | BRN | 7914363 | | InChI | InChI=1S/C5H3F2N/c6-4-1-5(7)3-8-2-4/h1-3H | | InChIKey | WRXAZPPGFLETFR-UHFFFAOYSA-N | | SMILES | C1=NC=C(F)C=C1F | | CAS DataBase Reference | 71902-33-5(CAS DataBase Reference) |
| Hazard Codes | Xi,F,N,Xn | | Risk Statements | 36/37/38-50-20/21/22-11 | | Safety Statements | 26-36/37/39-61-36/37 | | RIDADR | 1993 | | WGK Germany | 3 | | Hazard Note | Highly Flammable/Irritant | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29333990 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3 |
| | 3,5-Difluoropyridine Usage And Synthesis |
| Synthesis | Hydrogenolysis of 2,4,6-tribromo-3,5-difluoropyridine occurred rapidly giving
quantitative conversion to 3,5-difluoropyridine (5), with an isolated yield by distillation
of 63%.
 | | Chemical Properties | Liquid | | Preparation | Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8. | | References | [1] Patent: US2006/9643, 2006, A1. Location in patent: Page/Page column 4-5 |
| | 3,5-Difluoropyridine Preparation Products And Raw materials |
| Raw materials | Diethyl ether-->Lithium Aluminum Hydride-->Pentafluoropyridine-->2,3,5,6-Tetrafluoropyridine-->3,5-Dichloropyridine-->Potassium fluoride-->Sulfolane | | Preparation Products | 3,5-DIFLUORO-PYRIDIN-4-YLAMINE-->2,5-Difluoropyridine-->3,4,5-Trifluoropyridine-->3,5-Difluoro-4-pyridinecarboxaldehyde-->3,5-Dimethoxypyridine-->2,3,4,5-Tetrafluoropyridine |
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