- 3-Bromo-6-fluoro-2-methylpyridine
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- $200.00 / 1KG
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2025-09-25
- CAS:375368-83-5
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 5-BROMO-2-FLUORO-6-PICOLINE Basic information |
| | 5-BROMO-2-FLUORO-6-PICOLINE Chemical Properties |
| Boiling point | 189.5±35.0 °C(Predicted) | | density | 1.592±0.06 g/cm3(Predicted) | | refractive index | 1.5270-1.5310 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | -2.07±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow | | InChI | InChI=1S/C6H5BrFN/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3 | | InChIKey | GUYGQQWIKZLHTP-UHFFFAOYSA-N | | SMILES | C1(C)=NC(F)=CC=C1Br |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 5-BROMO-2-FLUORO-6-PICOLINE Usage And Synthesis |
| Chemical Properties | Light yellow powder | | Uses | 5-Bromo-2-fluoro-6-methylpyridine is a Light yellow powder, it is used as an intermediate in organic synthesis and is widely used in the fields of pesticide, medicine and materials science.
| | Synthesis | The general procedure for the synthesis of 3-bromo-2-methyl-6-fluoropyridine from 2-amino-5-bromo-6-methylpyridine was as follows: 5-bromo-2-amino-6-methylpyridine (5 g) was dissolved in pyridine hydrogen fluoride (35 mL). The reaction system was cooled to -20°C, followed by the slow addition of potassium nitrite (KNO2, 2.7 g). The reaction was continued by keeping the temperature low. Once the reaction was complete, it was slowly warmed to room temperature and stirred continuously for 4 hours. The reaction mixture was slowly poured into ice water (200 mL) and extracted with a solvent mixture of dichloromethane (50 mL) and ethyl acetate (EtOAc). The organic phases were combined, washed with 1N hydrochloric acid solution and concentrated under reduced pressure to give 5-bromo-2-fluoro-6-methylpyridine (4 g, 78% yield). | | References | [1] Patent: CN108341769, 2018, A. Location in patent: Paragraph 0021-0023; 0025-0027
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 22, p. 3979 - 3982 |
| | 5-BROMO-2-FLUORO-6-PICOLINE Preparation Products And Raw materials |
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