- Picroside I
-
- $50.00 / 20mg
-
2025-11-10
- CAS:27409-30-9
- Min. Order:
- Purity: 99.70%
- Supply Ability: 10g
- Picroside I
-
- $0.00 / 20mg
-
2023-02-24
- CAS:27409-30-9
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- PICROSIDE I
-
- $1.00 / 1g
-
2019-12-20
- CAS:27409-30-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: KG/T
|
| | PICROSIDE I Basic information |
| Product Name: | PICROSIDE I | | Synonyms: | PICROSIDE I;beta-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate), [1aS-[1aalpha,1bbeta,2beta(E),5abeta,6beta,6aalpha]]-;Picroside-Ⅰ;6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl,6-(3-phenyl-2-propenoate), [1aS-[1aα,1bβ,2β(E),5aβ,6β,6aα]]-;β-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-;[1aS-[1aalpha,1bbeta,2beta(E),5abeta,6beta,6aalpha]]-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-(3-phenyl-2-propenoate) beta-D-glucopyranoside;β-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate), [1aS-[1aα,1bβ,2β(E),5aβ,6β,6aα]]-;PICOLINIC ACID(P) | | CAS: | 27409-30-9 | | MF: | C24H28O11 | | MW: | 492.47 | | EINECS: | 248-445-1 | | Product Categories: | Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 27409-30-9.mol |  |
| | PICROSIDE I Chemical Properties |
| Boiling point | 778.6±60.0 °C(Predicted) | | density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | ethanol: soluble1mg/mL, clear, colorless | | pka | 12.70±0.70(Predicted) | | form | powder | | color | White | | InChIKey | BSYHSWKTXMTFNF-NTLZGZQOSA-N | | SMILES | [C@]12(CO)O[C@H]1[C@H]([C@]1([H])C=CO[C@@H](O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@]21[H])OC(=O)/C=C/C1=CC=CC=C1 |&1:0,4,5,6,11,13,14,16,17,19,24,r| |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29389090 |
| | PICROSIDE I Usage And Synthesis |
| Description | Picroliv is a hepatoprotective mixture of compounds that is isolated from an herb native to the Himalayas. Picroside I is an iridoid glycoside found in picroliv. By itself, picroside I blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver. Picroside I also enhances neurite outgrowth in PC12D cells induced by basic fibroblast growth factor and 7S nerve growth factor when given at 60 μM. At concentrations as low as 5 μM, picroside I enhances the ATPase activity of the efflux transporter P-glycoprotein. | | Chemical Properties | Yellow needle-shaped crystals, soluble in methanol, derived from Picrorhizoma Coptidis. | | Uses | Picroside I acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis. | | in vivo | Picroside I (20 mg/kg, o.p, 12 d) reduces AHR in the experimental asthma model and reduces OVA-associated IgE levels[2].
| Animal Model: | Ovalbumin (OVA) systematic sensitization BALB/c mice model[2] | | Dosage: | 0.2, 2.0 and 20 mg/kg
| | Administration: | Orally, once daily, from day 20 to day 32
| | Result: | Inhibited allergen-triggered inflammatory cell infiltration. |
| | IC 50 | STAT6 | | References | [1] C. GIRISH Suresh C P. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin[J]. Fundamental & Clinical Pharmacology, 2008, 22 6: 623-632. DOI: 10.1111/j.1472-8206.2008.00618.x
[2] YOGESH DWIVEDI. Picroliv and its Components Kutkoside and Picroside I Protect Liver Against Galactosamine-Induced Damage in Rats[J]. Basic & Clinical Pharmacology & Toxicology, 1992, 71 5: 383-387. DOI: 10.1111/j.1600-0773.1992.tb00566.x
[3] PING LI . Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells[J]. European journal of pharmacology, 2000, 406 2: Pages 203-208. DOI: 10.1016/s0014-2999(00)00662-2
[4] PING LI. Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells[J]. Life sciences, 2002, 71 15: Pages 1821-1835. DOI: 10.1016/s0024-3205(02)01949-5
[5] I A NAJAR. Modulation of P-glycoprotein ATPase activity by some phytoconstituents.[J]. Phytotherapy Research, 2010: 454-458. DOI: 10.1002/ptr.2951 |
| | PICROSIDE I Preparation Products And Raw materials |
|