- Abametapir
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- $29.00 / 1mL
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2026-01-16
- CAS:1762-34-1
- Min. Order:
- Purity: 99.44%
- Supply Ability: 10g
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| | 5,5'-DIMETHYL-2,2'-DIPYRIDYL Basic information |
| Product Name: | 5,5'-DIMETHYL-2,2'-DIPYRIDYL | | Synonyms: | 5,5’-dimethyl-2’-bipyridine;5,5-Dimethyl-2,2-dipyridine;Dimethylbipyridyl;2,2'-Bi(5-methylpyridine);5-methyl-2-(5-methyl-2-pyridyl)pyridine;5-methyl-2-(5-methylpyridin-2-yl)pyridine;5,5′-Dimethyl-2,2′-dipyridyl,5,5′-Dimethyl-2,2′-bipyridine;5,5-DIMETHYL-2,2-BIPYRIDINE | | CAS: | 1762-34-1 | | MF: | C12H12N2 | | MW: | 184.24 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 1762-34-1.mol |  |
| | 5,5'-DIMETHYL-2,2'-DIPYRIDYL Chemical Properties |
| Melting point | 114-117 °C(lit.) | | Boiling point | 140℃/3mm | | density | 1.060±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF: 15mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL | | form | powder to crystal | | pka | 4.78±0.32(Predicted) | | color | White to Yellow to Orange | | InChI | InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3 | | InChIKey | PTRATZCAGVBFIQ-UHFFFAOYSA-N | | SMILES | C1(C2=NC=C(C)C=C2)=NC=C(C)C=C1 | | CAS DataBase Reference | 1762-34-1(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | DW1766000 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | mouse,LD50,intraperitoneal,225mg/kg (225mg/kg),Toxicon. Vol. 23, Pg. 815, 1985. |
| | 5,5'-DIMETHYL-2,2'-DIPYRIDYL Usage And Synthesis |
| Uses | 5,5'-Dimethyl-2,2'-bipyridine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is also used as a raw material in the synthesis of dyestuffs and agrochemicals. It is used as a precursor for the preparation of 5-methyl-5'vinyl-2,2'-bipyridine. | | Definition | ChEBI: Abametapir is a member of bipyridines. | | Mechanism of action |
5 5'-Dimethyl-2,2-bipyridine works by inhibiting metalloproteinase enzymes that are essential for lice egg growth and development.
| | Synthesis |
2-Amino-5-methylpyridine ((Abametapir))(100) was converted to 2-bromo-5-methylpyridine (101) via the Sandmeyer reaction using bromine and sodium nitrite in 75% yield. Next, 101 was converted to abametapir (XIV) via a palladium-catalyzed homocoupling reaction in 79% yield. Abametapir was finally isolated by crystallization from a water/isopropanol mixture.
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| | 5,5'-DIMETHYL-2,2'-DIPYRIDYL Preparation Products And Raw materials |
| Raw materials | Dichloromethane-->Magnesium sulfate-->Triphenylphosphine-->Diglyme-->Sodium tert-butoxide-->Nickel(II) acetate tetrahydrate-->2-Bromo-5-methylpyridine-->5,6'-Dimethyl-[2,2']bipyridinyl-->6,6'-Dimethyl-2,2'-dipyridyl-->5-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE, 96%-->2-Amino-5-methylpyridine-->2-Bromo-6-methylpyridine-->2-Chloro-5-methylpyridine | | Preparation Products | BIPY531, 2,2'-([2,2'-Bipyridine]-5,5'-diyl)diacetonitrile-->5,5'-diMethoxycarbonyl-2,2'-bipyridine |
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