- Ozagrel hydrochloride
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- $71.00 / 50mg
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2025-09-13
- CAS:78712-43-3
- Min. Order:
- Purity: 99.80%
- Supply Ability: 10g
- Ozagrel hydrochloride
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- $15.00 / 1KG
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2021-07-02
- CAS:78712-43-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Ozagrel hydrochloride
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- $1.00 / 1kg
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2019-07-06
- CAS:78712-43-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: Customized
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| | Ozagrel hydrochloride Basic information |
| Product Name: | Ozagrel hydrochloride | | Synonyms: | OKY-046, (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrate hydrochloride;Ozagrel hydrate hydrochloride;Domenan;OKY-046 HCl;Vega;Ozagrel hydrochloride hydrate,(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate, OKY-046;(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid,hydrochloride (1:1);(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate | | CAS: | 78712-43-3 | | MF: | C13H13ClN2O2 | | MW: | 264.71 | | EINECS: | 928-470-0 | | Product Categories: | Inhibitors;Piperidones ,Piperidines ,Homopiperidines;Cardiovascular | | Mol File: | 78712-43-3.mol |  |
| | Ozagrel hydrochloride Chemical Properties |
| Melting point | 214-217° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | H2O: soluble | | form | solid | | color | white to off-white | | Water Solubility | H2O: soluble | | Merck | 14,6980 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. | | CAS DataBase Reference | 78712-43-3(CAS DataBase Reference) |
| RIDADR | 3077 | | WGK Germany | 2 | | RTECS | UD3380000 | | HS Code | 29332900 |
| | Ozagrel hydrochloride Usage And Synthesis |
| Description | Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1?Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2?isomerase (IC50 > 1 mM).1?Inhibits platelet aggregation2?in vitro?and arachidonate-induced arterial contraction?in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4. | | Uses | Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice. | | Uses | Antithrombotic;Thromboxane synthase inhibitor | | Definition | ChEBI: Ozagrel hydrochloride is an organic molecular entity. | | IC 50 | TXA2/TP | | References | [1] SEIJI HIRAKU . Pharmacological Studies on the TXA2 Synthetase Inhibitor (E)-3-[p(1H-lmidazol-1-Ylmethyl)Phenyl]-2-Propenoic Acid (OKY-046)[J]. Japanese journal of pharmacology, 1986, 41 3: Pages 393-401. DOI:10.1254/jjp.41.393
[2] JUN NAITO . Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets[J]. European journal of pharmacology, 1983, 91 1: Pages 41-48. DOI:10.1016/0014-2999(83)90359-x
[3] LEE C. EDMONDS Allan M L. Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death[J]. Life sciences, 1984, 35 17: Pages 1763-1768. DOI:10.1016/0024-3205(84)90273-x
[4] YOSHIRO TOMISHIMA. Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.[J]. BMC Gastroenterology, 2013, 13: 21. DOI:10.1186/1471-230x-13-21 |
| | Ozagrel hydrochloride Preparation Products And Raw materials |
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