- N-Boc-D-alaninol
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- $0.00 / 25Kg/Drum
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2026-05-19
- CAS:106391-86-0
- Min. Order: 25KG
- Purity: 98%min
- Supply Ability: 1000kg
- Boc-D-Ala-Ol
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- $0.00/ kg
-
2026-05-19
- CAS:106391-86-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
- Boc-D-Alaninol
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- $5.00 / 1KG
-
2025-05-26
- CAS:106391-86-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
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| | N-Boc-D-alaninol Basic information |
| Product Name: | N-Boc-D-alaninol | | Synonyms: | (R)-tert-butyl 1-hydroxypropan-2-ylcarbamate;REF DUPL: Boc-D-Alaninol;(R)-2-(Boc-amino)-1-propanol,(R)-(+)-2-(tert-Butoxycarbonylamino)-1-propanol, N-Boc-D-alaninol;Bayer Schering;(2R)-2-Aminopropan-1-ol, N-BOC protected;tert-Butyl [(2R)-1-hydroxyprop-2-yl]carbamate, D-Alaninol, N-BOC protected;(R)-2-(Boc-amino)-1-propanol 98%, optical purity ee: 98% (GLC);N-Boc-D-alaninol,99%e.e. | | CAS: | 106391-86-0 | | MF: | C8H17NO3 | | MW: | 175.23 | | EINECS: | 807-082-4 | | Product Categories: | Amino Alcohols;Boc-Amino acid series;Amino Acids;N-BOC | | Mol File: | 106391-86-0.mol |  |
| | N-Boc-D-alaninol Chemical Properties |
| Melting point | 58-61 °C(lit.) | | alpha | 11 º (c=1 in chloroform) | | Boiling point | 276.4±23.0 °C(Predicted) | | density | 1.025±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 12.11±0.46(Predicted) | | form | Solid | | color | White to Off-White | | Optical Rotation | [α]20/D +11°, c = 1 in chloroform | | Major Application | peptide synthesis | | InChI | InChI=1S/C8H17NO3/c1-6(5-10)9-7(11)12-8(2,3)4/h6,10H,5H2,1-4H3,(H,9,11)/t6-/m1/s1 | | InChIKey | PDAFIZPRSXHMCO-ZCFIWIBFSA-N | | SMILES | C(OC(C)(C)C)(=O)N[C@H](C)CO | | CAS DataBase Reference | 106391-86-0(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 10 | | HS Code | 29051990 | | Storage Class | 13 - Non Combustible Solids |
| | N-Boc-D-alaninol Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Used in the synthesis of antithrombotic nipecotamides. | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | GENERAL STEPS: 10 g (133 mmol) of (R)-2-aminopropan-1-ol and 14.8 g (146.5 mmol) of triethylamine were dissolved in 500 mL of tetrahydrofuran and the solution was cooled to 0 °C. A one-time addition of 30 g (133 mmol) of di-tert-butyl dicarbonate was added to the solution with stirring. The reaction mixture was stirred at room temperature for about 18 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in 300 ml of ethyl acetate and washed twice sequentially with 200 ml of water and once with 200 ml of saturated aqueous sodium chloride. The organic layer was dried with magnesium sulfate, filtered and concentrated under reduced pressure to give 22 g (94% yield) of the target product N-Boc-L-alaninol as a yellow oil. The structure of the product was confirmed by 1H-NMR (CDCl3): δ4.71 (multiple peaks, 1H), 3.72 (multiple peaks, 1H), 3.59-3.46 (multiple peaks, 2H), 2.86 (multiple peaks, 1H). | | References | [1] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7551 - 7556
[2] Patent: US7045545, 2006, B1. Location in patent: Page/Page column 26
[3] Letters in Organic Chemistry, 2010, vol. 7, # 5, p. 353 - 359
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4601 - 4608
[5] Patent: WO2014/159224, 2014, A1. Location in patent: Paragraph 00280 |
| | N-Boc-D-alaninol Preparation Products And Raw materials |
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