- 4-Quinolinecarbaldehyde
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- $15.00 / 1KG
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2021-07-09
- CAS:4363-93-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 4-Quinolinecarboxaldehyde Basic information |
| | 4-Quinolinecarboxaldehyde Chemical Properties |
| Melting point | 45-52 °C (lit.) | | Boiling point | 131-133°C 5mm | | density | 1.1599 (rough estimate) | | refractive index | 1.5000 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 2.95±0.13(Predicted) | | form | Crystalline Powder, Chunks, or Solid | | color | Off-white to yellow-brown | | Water Solubility | Slightly soluble in water. | | Sensitive | Air Sensitive | | BRN | 113072 | | InChI | InChI=1S/C10H7NO/c12-7-8-5-6-11-10-4-2-1-3-9(8)10/h1-7H | | InChIKey | MGCGJBXTNWUHQE-UHFFFAOYSA-N | | SMILES | N1C2C(=CC=CC=2)C(C=O)=CC=1 | | CAS DataBase Reference | 4363-93-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 37/38-36/37/38 | | Safety Statements | 24/25-36-26-36/37/39 | | WGK Germany | 3 | | F | 10 | | HazardClass | IRRITANT | | HS Code | 29334900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Skin Irrit. 2
STOT SE 3 |
| | 4-Quinolinecarboxaldehyde Usage And Synthesis |
| Chemical Properties | yellow to yellow-brown crystalline powder | | Occurrence | The common presence of 4-quinolinecarboxaldehyde in honey from Galicia (northwest of Spain). As opposed to other quinoline carboxylic acid derivatives, the 4- quinolinecarboxaldehyde species has not been correlated with the anti-diabetic properties of honey; nevertheless, it appears to be active against intestinal bacteria. | | Uses | 4-Quinolinecarboxaldehyde was used in the synthesis of lepidylamines. It also shows antimicrobial activity toward human intestinal bacteria such as Clostridium perfringens. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 35, p. 841, 1970 DOI: 10.1021/jo00828a074 | | Synthesis | The general procedure for the synthesis of 4-quinolinecarboxaldehyde from 4-methylquinoline was as follows: 5.0 g (35 mmol) of 4-methylquinoline and 5.0 g (45 mmol) of selenium dioxide were dissolved in toluene under argon protection and heated to reflux for 24 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane, washed sequentially with saturated saline and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the reaction was purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate (4:1, v/v) as eluent to give 4.0 g (73% yield) of the target product 4-quinolinecarboxaldehyde as a solid. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR) data: δ 10.54 (s, 1H), 9.22 (d, J = 4.3 Hz, 1H), 9.04 (d, J = 8.6 Hz, 1H), 8.24 (d, J = 8.2 Hz, 1H), 7.84 (t, J = 7.6 Hz, 1H), 7.81 (d, J = 4.3 Hz, 1H), 7.76 (t , J = 8.0 Hz, 1H). Nuclear magnetic resonance carbon (13C NMR) data: δ 193.1, 150.7, 149.5, 137.0, 130.4, 130.3, 129.6, 126.0, 124.7, 124.1. mass spectrometry (electrospray ionization) data: m/z 158.0 (100%) ([M + H]+), 130.2. | | References | [1] Tamara Rodríguez-Cabo. “Time-of-flight accurate mass spectrometry identification of quinoline alkaloids in honey.” Analytical and Bioanalytical Chemistry 407 20 (2015): 6159–6170. |
| | 4-Quinolinecarboxaldehyde Preparation Products And Raw materials |
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