1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE manufacturers
- Hesperin
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- $127.00
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2026-08-13
- CAS:4430-35-7
- Purity: 98.00%
- Supply Ability: 10g
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| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Basic information |
| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Chemical Properties |
| Boiling point | 385.9±25.0 °C(Predicted) | | density | 1.12±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Oil | | color | Colourless to Pale Yellow | | LogP | 0.959 (est) |
| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Usage And Synthesis |
| Description | 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities. It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 μM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 μM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 μM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson''s disease induced by 6-OHDA . 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model. | | Uses | 6-(Methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. | | Definition | ChEBI: 1-isothiocyanato-6-(methylsulfinyl)hexane is a sulfoxide. | | in vivo | Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice, suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice are fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin. The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but do not reduce these
triglycerides in Nrf2-null mice[1]. | | References | [1] TOSHIRO NOSHITA . Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity[J]. European Journal of Medicinal Chemistry, 2009, 44 12: Pages 4931-4936. DOI: 10.1016/j.ejmech.2009.08.005
[2] YASUJIRO MORIMITSU . Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi[J]. Mechanisms of Ageing and Development, 2000, 116 2: Pages 125-134. DOI: 10.1016/s0047-6374(00)00114-7
[3] TAKAHIRO NOMURA PHD . Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro[J]. Cancer Epidemiology, 2005, 29 2: Pages 155-160. DOI: 10.1016/j.cdp.2004.07.010
[4] FABIANA MORRONI . Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinsons disease[J]. Brain Research, 2014, 1589: Pages 93-104. DOI: 10.1016/j.brainres.2014.09.033
[5] YOKO FUKE PHD . Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells[J]. Cancer Epidemiology, 2006, 30 2: Pages 174-179. DOI: 10.1016/j.cdp.2005.10.005 |
| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Preparation Products And Raw materials |
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