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| | 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Basic information |
| | 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Chemical Properties |
| Melting point | 208-210 °C | | Boiling point | 507.24°C (rough estimate) | | density | 1.4163 (rough estimate) | | refractive index | 1.5740 (estimate) | | storage temp. | -20°C | | solubility | DMF: 20 mg/mL, clear, colorless | | form | Crystalline solid | | pka | 12.87±0.70(Predicted) | | color | White to Off-White | | λmax | 360nm(Phosphate buffer sol.)(lit.) | | BRN | 1693397 | | Stability: | Light Sensitive - Protect from Light | | InChIKey | PAVCYMSNMRWMAK-DMYIEBNJSA-N | | SMILES | [H]O[H].[H]O[H].CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Oc2ccc3C(C)=CC(=O)Oc3c2 | | LogP | 0.340 (est) | | CAS DataBase Reference | 37067-30-4(CAS DataBase Reference) | | EPA Substance Registry System | 2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]oxy]-4-methyl- (37067-30-4) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-21 | | TSCA | TSCA listed | | HS Code | 29321900 | | Storage Class | 11 - Combustible Solids |
| | 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Usage And Synthesis |
| Chemical Properties | 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is White Crystalline Solid | | Uses | 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is used for the assay of b-Acetylglucosaminidase. A fluorogenic substrate used for the diagnosis of GM2 gangliosidoses in leukocytes. Genetic defects in human b-hexosaminidase isozy mes (Hex A & Hex B) result in various clinical and biochemical types of GM2 gangliosidosis. They include Tay Sachs disease, Sandhoff disease and other forms. Fluorescence: max. Abs. l = 325nm, max. Em. l = 378nm | | Uses | 4-Methylumbelliferyl N-acetyl-β-D-glucosaminide has been used as a substrate for assaying
- β-N-acetylglucosaminidase (NAGase) from soil samples
- chitinase from Fusarium oxysporum using fluorimetric assay
- β-N-acetylhexosaminidases from Arabidopsis thaliana roots and leaves samples
| | General Description | 4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) contains chitin monomer, N-acetyl-D-glucosamine (NAG) and a 4-methylumbelliferone (7-hydroxy-4-methylcoumarin) (4-MUF) moiety. | | Biochem/physiol Actions | 4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) is a synthetic fluorogenic substrate for N-acetyl-β-D-glucosaminidase (NAGase). The enzyme functionality is assessed by its ability to hydrolyze the N-acetyl-D-glucosamine (NAG) residue in 4-MUF-NAG. 4-MUF-NAG is also a substrate for Chitinase and N-acetylhexosaminidase. |
| | 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Preparation Products And Raw materials |
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