| Company Name: |
Manhag Testing Technology Co., Ltd
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| Tel: |
020-3846 2365 19110442770 |
| Email: |
458677837@qq.com |
| Products Intro: |
Product Name:Lacidipine-[13C8]
CAS:1261432-01-2
Purity:1mg Package:1mg
|
| Company Name: |
SHANGHAI ZZBIO CO., LTD.
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| Tel: |
15102117276 19921389125 |
| Email: |
tech@zzbioco.com |
| Products Intro: |
Product Name:13C8]-Lacidipine
CAS:1261432-01-2
Package:1mg
|
| Company Name: |
CLEARSYNTH LABS LTD.
|
| Tel: |
+91-22-45045900 |
| Email: |
sales@clearsynth.com |
| Products Intro: |
Product Name:Lacidipine 13C8Q: What is
Lacidipine 13C8 Q: What is the CAS Number of
Lacidipine 13C8 Q: What is the storage condition of
Lacidipine 13C8 Q: What are the applications of
Lacidipine 13C8
CAS:1261432-01-2
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| | Lacidipine 13C8 Basic information |
| Product Name: | Lacidipine 13C8 | | Synonyms: | Lacidipine 13C8;Lacidipine 13C8Q: What is
Lacidipine 13C8 Q: What is the CAS Number of
Lacidipine 13C8 Q: What is the storage condition of
Lacidipine 13C8 Q: What are the applications of
Lacidipine 13C8;13C8]-Lacidipine | | CAS: | 1261432-01-2 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Lacidipine 13C8 Structure]() |
| | Lacidipine 13C8 Chemical Properties |
| | Lacidipine 13C8 Usage And Synthesis |
| Uses | Lacidipine-13C8 is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Zhang A, et al. Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem. 2013;32(4):1040-9.
[3] Cristofori P, et al. The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse. J Hypertens. 2000 Oct;18(10):1429-36. DOI:10.1097/00004872-200018100-00010 |
| | Lacidipine 13C8 Preparation Products And Raw materials |
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