| Company Name: |
DC Chemicals |
| Tel: |
021-58447131 13564518121 |
| Email: |
doncunbiosci@gmail.com |
SP-8356 manufacturers
- SP-8356
-
- $64.00
-
2026-06-02
- CAS:1454885-45-0
- Purity: 98.97%
- Supply Ability: 10g
- SP-8356
-
- $64.00
-
2026-06-02
- CAS:1454885-45-0
- Purity: 98.97%
- Supply Ability: 10g
|
| | SP-8356 Basic information |
| Product Name: | SP-8356 | | Synonyms: | SP-8356;SP8356,SP 8356;Bicyclo[3.1.1]hept-3-en-2-one, 4-[(1E)-2-(3,4-dihydroxy-5-methoxyphenyl)ethenyl]-6,6-dimethyl-, (1S,5R)-;SP-8356, 10 mM in DMSO | | CAS: | 1454885-45-0 | | MF: | C18H20O4 | | MW: | 300.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1454885-45-0.mol |  |
| | SP-8356 Chemical Properties |
| Boiling point | 502.7±50.0 °C(Predicted) | | density | 1.303±0.06 g/cm3(Predicted) | | solubility | DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 10 mg/ml | | pka | 9.20±0.15(Predicted) |
| | SP-8356 Usage And Synthesis |
| Description | SP-8356 an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling. | | References | [1] K. PAHK. A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation[J]. Journal of Translational Medicine, 2019. DOI: 10.1186/s12967-019-2024-y
[2] KISOO PAHK. SP-8356, a Novel Inhibitor of CD147-Cyclophilin A Interactions, Reduces Plaque Progression and Stabilizes Vulnerable Plaques in apoE-Deficient Mice.[J]. International Journal of Molecular Sciences, 2019, 21 1. DOI: 10.3390/ijms21010095
[3] CHUNG JU . Discovery of novel (1S)-(−)-verbenone derivatives with anti-oxidant and anti-ischemic effects[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 19: Pages 5421-5425. DOI: 10.1016/j.bmcl.2013.07.038
[4] SUNAM MANDER. SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling.[J]. Scientific Reports, 2019: 6595. DOI: 10.1038/s41598-019-41224-y |
| | SP-8356 Preparation Products And Raw materials |
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