| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:Cobolimab (anti-TIM-3)
CAS:2022215-65-0
Purity:ExactAb?, Validated, Carrier Free, Low Endotoxin, Azide Free Package:100μg Remarks:K14110
|
| Company Name: |
ShangHai Biochempartner Co.,Ltd
|
| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Cobolimab
CAS:2022215-65-0
Purity:95% Package:100ug;500ug;1mg
|
| Company Name: |
Guangzhou Hongyuan Chemical Co.,Ltd
|
| Tel: |
15817493340 |
| Email: |
981810490@qq.com |
| Products Intro: |
Product Name:Cobolimab
CAS:2022215-65-0
Purity:95% Package:1mg;1g;100g
|
|
| | Cobolimab Basic information |
| Product Name: | Cobolimab | | Synonyms: | Cobolimab;Research Grade Cobolimab(DHJ28401);TSR-022|||GSK4069889;Research Grade Cobolimab;Cobolimab (anti-TIM-3) | | CAS: | 2022215-65-0 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Cobolimab Structure]() |
| | Cobolimab Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Cobolimab Usage And Synthesis |
| Uses | Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC)[1][2][3]. | | References | [1] Falchook G S, et al. Phase 1 trial of TIM-3 inhibitor cobolimab monotherapy and in combination with PD-1 inhibitors nivolumab or dostarlimab (AMBER)[J]. 2022.
[2] Markham A. Dostarlimab: First Approval. Drugs. 2021 Jul;81(10):1213-1219. DOI:10.1007/s40265-021-01539-5
[3] Kuang Z, et al. A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy. Antib Ther. 2020 Nov 9;3(4):227-236. DOI:10.1093/abt/tbaa022
[4] Sun CY, et al. T cell exhaustion drives osteosarcoma pathogenesis. Ann Transl Med. 2021 Sep;9(18):1447. DOI:10.21037/atm-21-3928 |
| | Cobolimab Preparation Products And Raw materials |
|