3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
生物活性体外研究体内研究 用途与合成方法 MSDS 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester价格(试剂级) 上下游产品信息
| 中文名称 | 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester |
|---|---|
| 中文同义词 | 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯;化合物COR659;化合物COR659,10 MM DMSO 溶液 |
| 英文名称 | 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester |
| 英文同义词 | 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester;COR659;Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate;COR 659,Gamma-aminobutyric acid Receptor,sucrose,inhibit,chocolate,γ-Aminobutyric acid Receptor,GABA Receptor,COR-659,Inhibitor,COR659,alcohol;COR659, 10 mM in DMSO;2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylic acid methyl ester |
| CAS号 | 544450-68-2 |
| 分子式 | C16H16ClNO3S |
| 分子量 | 337.82 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 544450-68-2.mol |
| 结构式 | ![3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 结构式](CAS/20200611/GIF/544450-68-2.gif) |
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 性质
| 储存条件 | 4°C, away from moisture and light |
|---|---|
| 溶解度 | 二甲基亚砜：33.33 mg/mL（98.66 mM） |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
COR659 是有效的 GABAB 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。
COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA B receptor and an action at the cannabinoid CB1 receptor.
COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.
COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.
| Animal Model: | Male sP and Wistar rats. |
| Dosage: | 0, 2.5, 5 and 10 mg/kg. |
| Administration: | Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.). |
| Result: |
The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-137204 | COR659 | 544450-68-2 | 1 mg | 614元 |
| 2025/12/22 | HY-137204 | 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯 COR659 | 544450-68-2 | 10mM * 1mLin DMSO | 1106元 |