| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:TPC2-A1-N
CAS:136186-07-7
Purity:99.86% Package:1mg/RMB 1599
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2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- manufacturers
- TPC2-A1-N
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- $252.00 / 1mg
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2025-12-22
- CAS:136186-07-7
- Min. Order:
- Purity: 99.86%
- Supply Ability: 10g
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| | 2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- Basic information |
| | 2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- Chemical Properties |
| Boiling point | 536.9±50.0 °C(Predicted) | | density | 1.546±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | pka | 5.05±0.60(Predicted) | | color | White to off-white | | SMILES | O=C(/C(C#N)=C(O)/C1=CC(Cl)=CC(Cl)=C1)NC2=CC=C(C=C2)C(F)(F)F |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- Usage And Synthesis |
| Uses | TPC2-A1-N is a powerful and Ca2+-permeable agonist oftwo porechannel2(TPC2), which plays its role by mimicking the physiological actionsofNAADP. TPC2-A1-P reproduciblyevokes significant Ca2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells[1][2]. | | Biological Activity | TPC2-A1-N is a selective two pore segment channel 2 (TCP2) agonist th at mimics the action of NAADP where it selectively induces fast Ca2+ signals (EC50 = 7.8 μM) in a TCP2-dependent manner, without potency toward TRPML1/2/3. In contrast, TPC2-A1-N is a much weaker Na+ current inducer when compared to PI(3,5)P2 and TPC2-A1-P. TPC2-A1-N, but not the Na+ signals agonist TPC2-A1-P causes TPC2-dependent alkalinization of lysosomal lumen Ca2+ stores (10 μM, TPC2-expressing HeLa cells), while TPC2-A1-P, but not TPC2-A1-N, activates TPC2-dependent lysosomal exocytosis (30 μM, murine macrophages). | | References | [1] Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife DOI:10.7554/eLife.54712
[2] Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41(8):582-594. DOI:10.1016/j.tips.2020.06.002 |
| | 2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials |
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