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| | Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Basic information |
| | Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Chemical Properties |
| Boiling point | 519.0±50.0 °C(Predicted) | | density | 1.274±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml) | | form | solid | | pka | 8.67±0.40(Predicted) | | color | Pale yellow | | Water Solubility | Water: Insoluble | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | | InChIKey | KLKWHGQIUKBXKT-UHFFFAOYSA-N | | SMILES | CC(S1)=C(C)C2=C1N=CN=C2NC3CN(CC4=CC=CC=C4)CC3.O=S(C5=CC=CC=C5)(O)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Usage And Synthesis |
| Description | Fasnall (CAS 929978-58-5) is a potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model.1Reduces HIV-1 virion production by 90% (EC50=213 nM).2 | | Definition | ChEBI: Fasnall is a racemate comprising equimolar amounts of (R)- and (S)-Fasnall. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer. It has a role as a fatty acid synthesis inhibitor, an EC 2.3.1.85 (fatty acid synthase) inhibitor, an apoptosis inducer and an anti-HIV agent. It contains a (R)-Fasnall and a (S)-Fasnall. | | References | [1] YAZAN ALWARAWRAH . Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer[J]. Cell Chemical Biology, 2016, 23 6: Pages 678-688. DOI:10.1016/j.chembiol.2016.04.011
[2] MANJUSHA M KULKARNI. Cellular fatty acid synthase is required for late stages of HIV-1 replication.[J]. Retrovirology, 2017: 45. DOI:10.1186/s12977-017-0368-z |
| | Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Preparation Products And Raw materials |
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