2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

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CAS:2359705-88-5
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Products Intro: Product Name:3-(4-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS:2359705-88-5
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2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Basic information
Product Name:2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Synonyms:2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-;Lenalidomide-F;3-(4-Fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CAS:2359705-88-5
MF:C13H11FN2O3
MW:262.24
EINECS:
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Mol File:2359705-88-5.mol
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Structure
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties
Boiling point 542.9±50.0 °C(Predicted)
density 1.461±0.06 g/cm3(Predicted)
form Solid
pka10.63±0.40(Predicted)
color Off-white to gray
Safety Information
MSDS Information
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Usage And Synthesis
UsesLenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1].
IC 50Cereblon
References[1] Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974. DOI:10.1016/j.ejmech.2023.115974
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials
Tag:2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-(2359705-88-5) Related Product Information
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