1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-

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1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- manufacturers

  • BTB09089
  • BTB09089 pictures
  • $65.00
  • 2026-06-02
  • CAS:245728-44-3
  • Purity: 99.78%
  • Supply Ability: 10g
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Basic information
Product Name:1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-
Synonyms:1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-;GPR65 agonist (BTB09089);BTB09089;BTB09089, 10 mM in DMSO;GPR65 agonist
CAS:245728-44-3
MF:C14H12Cl2N4OS2
MW:387.31
EINECS:
Product Categories:
Mol File:245728-44-3.mol
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Structure
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Chemical Properties
Boiling point 500.6±60.0 °C(Predicted)
density 1.57±0.1 g/cm3(Predicted)
pka-0.51±0.40(Predicted)
form Solid
color Yellow to orange
InChIInChI=1S/C14H12Cl2N4OS2/c1-19-11-6-17-20(2)13(21)12(11)23-14(18-19)22-7-8-3-4-9(15)5-10(8)16/h3-6H,7H2,1-2H3
InChIKeyPIAWQVCBQLTEIY-UHFFFAOYSA-N
SMILESS1C2C(=O)N(C)N=CC=2N(C)N=C1SCC1=CC=C(Cl)C=C1Cl
Safety Information
MSDS Information
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Usage And Synthesis
UsesBTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages[1].
in vivo

BTB09089 (5-20 μM, 8 μL; i.c.v.; 6 hours prior to MCAO) reduces cerebral ischaemia-reperfusion injury in rats[2].

Animal Model:Adult male SD rats (270-280 g), middle cerebral artery occlusion (MCAO) model[2]
Dosage:5, 10 and 20 μM, 8 μL
Administration:Intracerebroventricular injection, six hours prior to MCAO
Result:Up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72 h after MCAO.
References[1] Onozawa Y, et al. Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro. Eur J Pharmacol. 2012 May 15;683(1-3):325-31. DOI:10.1016/j.ejphar.2012.03.007
[2] Ma XD, et al. TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Exp Neurol. 2017 Jul;293:115-123. DOI:10.1016/j.expneurol.2017.03.023
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Preparation Products And Raw materials
Tag:1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-(245728-44-3) Related Product Information
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