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| | 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Basic information |
| Product Name: | 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine | | Synonyms: | 3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]-PYRAZINE;3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE,95% MIN(HPLC);1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)- | | CAS: | 486460-20-2 | | MF: | C6H3F3N4 | | MW: | 188.11 | | EINECS: | | | Product Categories: | | | Mol File: | 486460-20-2.mol | ![3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Structure](CAS/GIF/486460-20-2.gif) |
| | 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Chemical Properties |
| density | 1.69±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -2.40±0.30(Predicted) |
| | 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Usage And Synthesis |
| Uses | 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine can be used as reactant/reagent in synthetic preparation of 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for treatment or prevention of diabetes. | | Synthesis | General method: 10 mmol of compound 3 (CAS:1447800-65-8) was dissolved in 50 mL of toluene and 20 mmol of triethylamine was slowly added to the reaction system at room temperature with continuous stirring for 1 hour. The reaction process was monitored by thin layer chromatography (TLC). After the reaction was complete, the reaction mixture was slowly poured into 25 g of ice-water mixture, stirred thoroughly and left to stratify. The organic phase was separated and washed with 2 x 10 mL of cold water, followed by drying the organic phase with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give compound 4 in good yield. | | References | [1] Letters in Organic Chemistry, 2013, vol. 10, # 5, p. 348 - 352 |
| | 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Preparation Products And Raw materials |
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