- 1-BOC-3-(METHOXY)AZETIDINE
-
- $15.00 / 1KG
-
2021-07-13
- CAS:429669-07-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 1-BOC-3-(METHOXY)AZETIDINE
-
- $15.00 / 1KG
-
2021-07-10
- CAS:429669-07-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
|
| | 1-BOC-3-(METHOXY)AZETIDINE Basic information |
| Product Name: | 1-BOC-3-(METHOXY)AZETIDINE | | Synonyms: | 1-BOC-3-(METHOXY)AZETIDINE;1-Azetidinecarboxylicacid,3-methoxy-,1,1-dimethylethylester(9CI);3-Methoxy-azetidine-1-carboxylic acid tert-butyl ester;3-Methoxyazetidine, N-BOC protected;tert-Butyl 3-methoxyazetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-methoxyazetidine;tert-butyl 3-Methoxyazetidine-1-carboxylate;N-Boc-3-Methoxyazetidine;1-Azetidinecarboxylicacid, 3-Methoxy-, 1,1-diMethylethyl ester | | CAS: | 429669-07-8 | | MF: | C9H17NO3 | | MW: | 187.24 | | EINECS: | | | Product Categories: | METHOXY | | Mol File: | 429669-07-8.mol |  |
| | 1-BOC-3-(METHOXY)AZETIDINE Chemical Properties |
| Boiling point | 232.8±33.0 °C(Predicted) | | density | 1.06±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -2.86±0.40(Predicted) | | Appearance | Colorless to light yellow Liquid |
| HazardClass | IRRITANT | | HS Code | 2918199890 |
| | 1-BOC-3-(METHOXY)AZETIDINE Usage And Synthesis |
| Synthesis | To a solution of tetrahydrofuran (THF, 50 mL) of tert-butyl 3-hydroxy-azetidine-1-carboxylate (0.8 g, 4.62 mmol) was added sodium hydride (60% dispersed in mineral oil, 0.74 g, 18.5 mmol). The reaction mixture was stirred at 0 °C for 0.5 h, followed by the slow addition of iodomethane (2.8 mL, 46.2 mmol). The reaction mixture was stirred overnight at room temperature. After completion of the reaction, it was quenched with water (50 mL) and extracted with ethyl acetate (EtOAc, 30 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 3-methoxy-N-Boc-azetidine (0.8 g, 93% yield) as an oil.1H NMR (400 MHz, CDCl3): δ 4.11-4.13 (m, 1H), 4.04-4.08 (m, 2H), 3.79- 3.83 (m, 2H), 3.27 (s, 3H), 1.43 (s, 9H). | | References | [1] Organic Letters, 2014, vol. 16, # 3, p. 856 - 859
[2] Patent: WO2013/53690, 2013, A1. Location in patent: Page/Page column 37; 38
[3] Patent: US2004/14962, 2004, A1. Location in patent: Page/Page column 135
[4] Patent: US2008/214815, 2008, A1. Location in patent: Page/Page column 16
[5] Patent: WO2011/63502, 2011, A1. Location in patent: Page/Page column 50 |
| | 1-BOC-3-(METHOXY)AZETIDINE Preparation Products And Raw materials |
|