4,4'-(dithiodicarbonothioyl)dimorpholine manufacturers
- JX06
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- $64.00 / 10mg
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2026-03-12
- CAS:729-46-4
- Min. Order:
- Purity: 99.66%
- Supply Ability: 10g
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| | 4,4'-(dithiodicarbonothioyl)dimorpholine Basic information |
| Product Name: | 4,4'-(dithiodicarbonothioyl)dimorpholine | | Synonyms: | 4,4'-(dithiodicarbonothioyl)dimorpholine;Morpholine, 4,4-(dithiodicarbonothioyl)bis-;Bis(morpholinocarbonothioyl) persulfide;JX 06;Bis(morpholinothiocarbonyl) disulfide;Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK;JX06, 10 mM in DMSO;DI(4-MORPHOLINYL)DITHIOPEROXYANHYDRIDE | | CAS: | 729-46-4 | | MF: | C10H16N2O2S4 | | MW: | 324.51 | | EINECS: | 211-980-6 | | Product Categories: | | | Mol File: | 729-46-4.mol |  |
| | 4,4'-(dithiodicarbonothioyl)dimorpholine Chemical Properties |
| Melting point | 136-137 °C | | Boiling point | 466.3±55.0 °C(Predicted) | | density | 1.4302 (rough estimate) | | refractive index | 1.5650 (estimate) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 0.58±0.20(Predicted) | | form | A solid | | color | White to off-white | | EPA Substance Registry System | Morpholine, 4,4'-(dithiodicarbonothioyl)bis- (729-46-4) |
| | 4,4'-(dithiodicarbonothioyl)dimorpholine Usage And Synthesis |
| Uses | JX 06 is a covalent inhibitor of Potent Covalent Pyruvate Dehydrogenase Kinase (PDK). | | Biological Activity | JX06 is a potent, PDK1-selective, covalent pyruvate dehydrogenase (PDH) kinase (PDHK, PDK) inhibitor (PDK1/2/3 IC50 = 49/101/313 nM; PDK4 IC50 >10 μM, IC50 >10 μM against >300 other kinases). JX06 inhibits cellular PDK substrate PDHA1 Ser293/232 phosphorylation, resulting in reduced aerobic glycolysis and cancer proliferation in cultures (1-10 μM) and in mice in vivo (40-80 mg/kg via daily i.p. injection; A549 & HT-29 xenografts). JX06 is shown to target PDK1 Cys240 for covalent modification. | | in vivo | JX06 (40-80mg/kg; i.p. for 21 days) inhibits tumor growth in vivo[1]. | Animal Model: | A549 subcutaneous xenograft mice[1] | | Dosage: | 40, 80mg/kg | | Administration: | I.p. injections for 21 days | | Result: | Reduced tumor weights and 67.5% tumor volume at the dose of 80 mg/kg compared with the vehicle control.
Well tolerated at the administration dose.
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| | storage | Store at -20°C |
| | 4,4'-(dithiodicarbonothioyl)dimorpholine Preparation Products And Raw materials |
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