3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-

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3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- manufacturers
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Basic information
Product Name:3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-
Synonyms:3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-;GPR30 agonist-1
CAS:415919-74-3
MF:C19H17BrFNO
MW:374.25
EINECS:
Product Categories:
Mol File:415919-74-3.mol
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Structure
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Chemical Properties
Boiling point 446.7±45.0 °C(Predicted)
density 1.394±0.06 g/cm3(Predicted)
solubility DMSO : 50 mg/mL (133.60 mM; ultrasonic and warming and heat to 80°C)
pka4.32±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Usage And Synthesis
UsesGPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1].
in vivo

GPR30 agonist-1 (compound 5408-0877) (1 nM-10 μM) induces a concentration-dependent relaxation in carotid arteries from both male and female rats. GPR30 agonist-1-induced relaxation is abolished by endothelium removal and abrogated in the presence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (100 μM)[1].

References[1] Brad R S Broughton, et al. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1055-61. DOI:10.1152/ajpheart.00878.2009
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Preparation Products And Raw materials
Tag:3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-(415919-74-3) Related Product Information
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