6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1)

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6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1) Basic information
Product Name:6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1)
Synonyms:6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1);Senexin A hydrochloride
CAS:1780390-76-2
MF:C17H15ClN4
MW:310.79
EINECS:
Product Categories:
Mol File:1780390-76-2.mol
6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1) Structure
6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1) Chemical Properties
solubility Soluble to 100 mM in DMSO
Safety Information
MSDS Information
6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1) Usage And Synthesis
UsesSenexin A is a useful intermediate.
in vivo

Senexin A hydrochloride (5 times daily) completely reverses the tumor-promoting effects of chemotherapy. Senexin A hydrochloride had no significant toxicity to body weight, organ weights, or blood cell counts in C57BL/6 mice during treatment. Senexin A hydrochloride treatment significantly improves A549/MEF tumor response to Doxorubicin (HY-15142A)[1].

IC 50CDK8: 280 nM (IC50); CDK8: 0.83 μM (Kd); CDK19: 0.31 μM (Kd)
storageStore at +4°C
6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-, hydrochloride (1:1) Preparation Products And Raw materials
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