4-(dimethylamino)benzenesulphonic acid manufacturers
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| | 4-(dimethylamino)benzenesulphonic acid Basic information |
| | 4-(dimethylamino)benzenesulphonic acid Chemical Properties |
| Melting point | 270.5°C | | density | 1.3156 (rough estimate) | | refractive index | 1.5364 (estimate) | | storage temp. | Store at room temperature | | pka | -1.15±0.50(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C8H11NO3S/c1-9(2)7-3-5-8(6-4-7)13(10,11)12/h3-6H,1-2H3,(H,10,11,12) | | InChIKey | KZVBBVPCVQEVQK-UHFFFAOYSA-N | | SMILES | C1(S(O)(=O)=O)=CC=C(N(C)C)C=C1 | | EPA Substance Registry System | Benzenesulfonic acid, 4-(dimethylamino)- (121-58-4) |
| | 4-(dimethylamino)benzenesulphonic acid Usage And Synthesis |
| Uses | N,N-Dimethylsulfanilic Acid, is a benzoic acid derivative acting as a weak yeast sirtuin inhibitors. | | Synthesis | 4-(Dimethylamino)benzenesulfonic acid was synthesized as follows: to a 250 mL three-necked round-bottomed flask, a solution of N,N-dimethylaniline (20 g, 165.29 mmol) in ether (40 mL) was added under ice bath conditions. Subsequently, a solution of sulfuric acid (16.1 g, 161.00 mmol) in ether (160 mL) was added slowly and dropwise. Upon completion of the reaction, the ether solvent was removed by rotary evaporator. The resulting mixture was reacted under stirring conditions at 170 °C under vacuum for 4 hours. Eventually, 10.5 g of 4-(dimethylamino)benzenesulfonic acid was obtained in 32% yield and the product was a white solid. | | References | [1] Patent: US2010/256092, 2010, A1. Location in patent: Page/Page column 134
[2] European Journal of Medicinal Chemistry, 2001, vol. 36, # 10, p. 809 - 828
[3] Synthesis, 1982, # 4, p. 277 - 280
[4] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 37
[5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 60 |
| | 4-(dimethylamino)benzenesulphonic acid Preparation Products And Raw materials |
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