- 1-Cyclopropylpiperazine
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- $0.00 / 25KG
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2025-12-01
- CAS:20327-23-5
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 10000KGS
- 1-Cyclopropylpiperazine
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- $1.10 / 1g
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2025-11-18
- CAS:20327-23-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
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| | 1-Cyclopropylpiperazine Basic information |
| Product Name: | 1-Cyclopropylpiperazine | | Synonyms: | 1-Cyclopropylpiperazine;(Piperazin-1-yl)cyclopropane;N-cyclopropylpiperazine;Cyclopropyl piperazine;Piperazine,1-cyclopropyl-;1-Cyclopropylpiperazine >;1-Cyclopropylpiperazine ISO 9001：2015 REACH;1-(Cyclopropyl Phenyl)Piperazine | | CAS: | 20327-23-5 | | MF: | C7H14N2 | | MW: | 126.2 | | EINECS: | 807-993-7 | | Product Categories: | Piperazines;Pyridines | | Mol File: | 20327-23-5.mol |  |
| | 1-Cyclopropylpiperazine Chemical Properties |
| Boiling point | 43°C/7mm | | density | 0.94 | | refractive index | 1.4804 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 9.23±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow | | InChI | InChI=1S/C7H14N2/c1-2-7(1)9-5-3-8-4-6-9/h7-8H,1-6H2 | | InChIKey | HNZJIWIXRPBFAN-UHFFFAOYSA-N | | SMILES | N1(C2CC2)CCNCC1 |
| Hazard Codes | Xi | | RIDADR | 3267 | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 2933599590 |
| | 1-Cyclopropylpiperazine Usage And Synthesis |
| Uses |
1-cyclopropylpiperazine is a piperazine derivative known in the literature by synonyms such as N-cyclopropylpiperazine and 4-cyclopropylpiperazine. It has been used in the preparation of some tri- and tetrasubstituted ureas with histamine H3 antagonist receptor activity, 3-amido-4- anilinoquinolines series as CSF-1R kinase inhibitors, for the synthesis of cyclopropyl amines as modulators of the histamine H3 receptor, sulfonamide compounds as cysteine protease inhibitors, N-oxides as antibacterial agents and in the treatment of the disease caused by helicobacter infection[1].
| | Synthesis | Tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) was used as a raw material, which was dissolved in a 1,4-dioxane solution (4.37 mL, 17.50 mmol) in 4 M HCl. The reaction mixture was stirred at room temperature for 3 hours under nitrogen protection. Upon completion of the reaction, the mixture was filtered and washed with ether to afford the crude product 1-cyclopropylpiperazine (0.659 g) as a white solid. Subsequently, the crude product was purified by ion exchange chromatography through SCX column. The target compound 1-cyclopropylpiperazine was eluted from the column using 3.5 M NH3/MeOH solution, and the pure grades were collected and evaporated to dryness to give the final 1-cyclopropylpiperazine (0.264 g, 59.7% yield) as a yellow oil. The structure of the product was confirmed by 1H NMR (399.9 MHz, DMSO-d6) with chemical shifts δ 0.25-0.30 (2H, m), 0.35-0.40 (2H, m), 1.54-1.60 (1H, m), 2.43 (4H, t), 2.60-2.65 (4H, t), 3.30 (1H, s). | | References | [1] G. Kean. “DFT, FT-Raman, and FT-IR investigations of 1-cyclopropylpiperazine.” Journal of Structural Chemistry 54 6 (2014): 1044–1054.
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| | 1-Cyclopropylpiperazine Preparation Products And Raw materials |
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