4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
| 中文名称 | 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid |
|---|---|
| 中文同义词 | 4-氨基-5-(对甲苯磺酰氧基)萘-2,7-二磺酸;化合物 T16351;化合物 NSC16168 |
| 英文名称 | 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid |
| 英文同义词 | 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid;1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid;4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid;8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid;4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid;2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-;NSC16168,NSC-16168 |
| CAS号 | 6837-93-0 |
| 分子式 | C17H15NO9S3 |
| 分子量 | 473.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 6837-93-0.mol |
| 结构式 |  |
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid 性质
| 密度 | 1.5197 (rough estimate) |
|---|---|
| 折射率 | 1.7000 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：31.25 mg/mL（66.00 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | -1.16±0.40(Predicted) |
| 颜色 | 米白色至灰色 |
NSC16168 是特异性 ERCC1-XPF 的抑制剂，其 IC50 值为0.42 μM。NSC16168 可抑制 DNA 修复，增强 CDDP 对癌症的疗效。
IC50: 0.42 μM (ERCC1-XPF).
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
Cell Viability Assay.
| Cell Line: | H460 cells. |
| Concentration: | 0-50 μM. |
| Incubation Time: | 2 h. |
| Result: | Potentiated cisplatin efficacy in cancer cells. |
NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.
| Animal Model: |
2.5×10
6
H460 cells were injected s.c. in the right flank of each mouse.
|
| Dosage: | 20 mg/kg. |
| Administration: | IP, twice daily for 10 days. |
| Result: |
The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects.
The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections. |
类别
有毒物品毒性分级
低毒急性毒性
口服-大鼠LD50: 11500 毫克/公斤刺激数据
眼睛-兔子100 毫克/24小时 重度可燃性危险特性
可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾储运特性
库房通风低温干燥灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水