2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro-

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2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro- Basic information
Product Name:2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro-
Synonyms:2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro-;WAY-380064-A;PRMT5-IN-46
CAS:380192-76-7
MF:C19H22ClNO2
MW:331.84
EINECS:
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Mol File:380192-76-7.mol
2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro- Structure
2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro- Chemical Properties
Boiling point 497.4±45.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
pka13.85±0.20(Predicted)
Safety Information
MSDS Information
2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro- Usage And Synthesis
UsesPRMT5-IN-46 (compound 278) inhibits PRMT5 with IC50 of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases[1].
References[1] DUNCAN, et al. PRMT5 inhibitors and uses thereof. WO2014100695. World Intellectual Property Organization. 2014-06-26.
2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro- Preparation Products And Raw materials
Tag:2(1H)-Isoquinolineethanol, α-[[(4-chlorophenyl)methoxy]methyl]-3,4-dihydro-(380192-76-7) Related Product Information
UNC 1999 GSK-3326595 UNC-0642 UNC0638 DS-3201 MRTX-1719