Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]-

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Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- Basic information
Product Name:Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]-
Synonyms:Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]-;BG 47;BG47;BG-47
CAS:1628784-54-2
MF:C25H22N4O2S
MW:442.53
EINECS:
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Mol File:1628784-54-2.mol
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- Structure
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- Chemical Properties
Boiling point 586.1±50.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
pka8.61±0.48(Predicted)
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MSDS Information
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- Usage And Synthesis
DescriptionBG47 is a novel probe for chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light.
UsesBG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research[1].
IC 50HDAC1; HDAC2
References[1] Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23. DOI:10.1038/nchembio.2042
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- Preparation Products And Raw materials
Tag:Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]-(1628784-54-2) Related Product Information
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