Miglustat

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Miglustat Suppliers list
Company Name: DIPHARMA SA  
Tel: + 39 02 38228.241
Email: europe@www.dipharma.com
Company Name: NAVINTA LLC  
Tel: (609) 883 1135
Email: sales@navinta.com
Company Name: Matrix Pharmacorp Private Limited  
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Company Name: APICORE LLC (A WHOLLY OWNED SUB OF RK PHARMA INC)  
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Email: dmfcep000062name@qq.com
Company Name: Taizhou Baoran Trading Co., Ltd.  
Tel: 15888667641
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Miglustat Basic information
Product Name:Miglustat
Synonyms:Miglustat
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Miglustat Structure
Miglustat Chemical Properties
Safety Information
MSDS Information
Miglustat Usage And Synthesis
DescriptionThis orally active glucosylceramide glucosyltransferase inhibitor, was launched for the treatment of type I Gaucher’s disease. Miglustat (XVI) has been developed and launched by Oxford GlycoSciences (OGS; now Celltech) and Actelion.
UsesTreatment of glycolipid storage diseases.
Brand nameZavesca(Actelion).
SynthesisMiglustat was originally discovered at Searle (now Pfizer) and an enzymatic oxidation was employed in the synthesis. D-Glucose (125) was subjected to reductive amination with n-butylamine in ethanol under 4 atm of hydrogen in the presence of Pd/C catalyst at 60 oC to give N-butylglucamine HCl salt (126) in 90% yield. Nbutylglucamine (126) then was submitted to a selective microorganism oxidation by Gluconobacter Oxidans (DSM 2003) cell paste in water to give 6-(butylamino)-6-deoxy-a- L-sorbofuranose HCl salt (127) in 80 % yield. Finally, compound 127 was cyclized and reduced in situ with hydrogen over Pd/C at 4000 atm in ethanol/water to give miglustat (XVI) in 45% overall yield from D-glucose (125).

Miglustat Preparation Products And Raw materials
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