| Company Name: |
Creative Enzymes |
| Tel: |
1-516-855-7709 |
| Email: |
info@creative-enzymes.com |
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| Product Name: | FLICE | | Synonyms: | MCH5;MCH51;MACH;MACH-1;MACH2;HUMAN CASPASE-8;FLICE;FLICE3 | | CAS: | 179241-78-2 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![FLICE Structure]() |
| | FLICE Chemical Properties |
| storage temp. | −70°C | | form | buffered aqueous solution | | biological source | rabbit | | Specific Activity | ≥1,000units/mg protein |
| Hazard Codes | Xi,T | | Risk Statements | 36/37/38-61 | | Safety Statements | 26-36-45-53 | | WGK Germany | 2 | | Storage Class | 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | | Hazard Classifications | Eye Irrit. 2
Repr. 1B
Skin Irrit. 2
Skin Sens. 1 |
| | FLICE Usage And Synthesis |
| Uses | Human recombinant C−terminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213−496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag. | | General Description | Human recombinant Cterminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag. | | Biochem/physiol Actions | Caspase 8 is at the top of the hierarchy of the caspase cascade and is considered an initiator caspase. It exists in the cell as an inactive 55kDa proenzyme. It is converted to the active form, consisting of 18kDa and 11kDa subunits, upon its recruitment to the cytoplasmic domain of activated death receptors such as CD95 or TNFR via the adapter protein FADD. The activation of the proenzyme is triggered by the protein′s aggregation, which leads to auto- or transprocessing. Caspase8 activates downstream caspases (caspases3, 6, and 7) that cleave key cellular substrates and lead to apoptotic death of the cells. |
| | FLICE Preparation Products And Raw materials |
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