| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:IM-156 acetate
CAS:2043654-54-0
Purity:90% Package:1mg/RMB 350
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:IM-156 (acetate)
CAS:2043654-54-0
Purity:98% Package:1mg;5mg;10mg
|
IM-156 (acetate) manufacturers
- IM-156 acetate
-
- $50.00 / 1mg
-
2025-08-21
- CAS:2043654-54-0
- Min. Order:
- Purity: 90%
- Supply Ability: 10g
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| | IM-156 (acetate) Basic information |
| | IM-156 (acetate) Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml | | form | A solid |
| | IM-156 (acetate) Usage And Synthesis |
| Biological Activity | IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 2.2 μM) and an activator of AMP-activated protein kinase α (AMPKα).1,2 It reduces the oxygen consumption rate (OCR; IC50 = 3.3 μM) and decreases mitochondrial ATP production in Eμ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 μM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.3,4 | | References | 1.Izreig, S., Gariepy, A., Kaymak, I., et al.Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatmentCell Rep. Med.1(2)100014(2020)
2.Ju, K.D., Kim, H.J., Tsogbadrakh, B., et al.HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosisAm. J. Physiol. Renal. Physiol.310(5)F342-F350(2016)
3.Lam, T.G., Jeong, Y.S., Kim, S.-A., et al.New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathwaysCancer Sci.109(3)699-709(2018)
4.Bang, E., Lee, B., Park, J.-O., et al.The improving effect of HL271, a chemical derivative of metformin, a popular drug for type II diabetes mellitus, on aging-induced cognitive declineExp. Neurobiol.27(1)45-56(2018) |
| | IM-156 (acetate) Preparation Products And Raw materials |
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