2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-

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Company Name: ShangHai ChuanQian Chemcial Technique Centre  
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2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- manufacturers

  • UNC10112785
  • UNC10112785 pictures
  • $1210.00
  • 2026-07-14
  • CAS:748142-06-5
  • Purity: 98.12%
  • Supply Ability: 10g
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- Basic information
Product Name:2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-
Synonyms:2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-
CAS:748142-06-5
MF:C19H18N6
MW:330.39
EINECS:
Product Categories:
Mol File:748142-06-5.mol
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- Structure
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- Chemical Properties
density 1.28±0.1 g/cm3(Predicted)
pka2.13±0.10(Predicted)
Safety Information
MSDS Information
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- Usage And Synthesis
DescriptionUNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures.
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- Preparation Products And Raw materials
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