1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

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1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:FMK
CAS:821794-92-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:FMK
CAS:821794-92-7
Purity:98% HPLC LCMS Package:10G;20G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:FMK
CAS:821794-92-7
Purity:>98% Package:10 mg Remarks:Reach out to us for more information about custom solutions.
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Products Intro: Product Name:1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-6-yl]-2-fluoroethanone
CAS:821794-92-7
Purity:Min98% HPLC Package:1KG;1USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
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Products Intro: Product Name:FMK
CAS:821794-92-7
Purity:99% Package:5KG;1KG Remarks:FMK

1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone manufacturers
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Basic information
Product Name:1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Synonyms:FMK;1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone;FMK - RSK inhibitor Fmk;1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone;RSK2 kinase inhibitor;Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-;1-[5-amino-9-(3-hydroxypropyl)-7-(4-methylphenyl)-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-8-yl]-2-fluoro-ethanone;Fluoromethyl Ketone
CAS:821794-92-7
MF:C18H19FN4O2
MW:342.37
EINECS:
Product Categories:Akt;mTOR;PI3K;API
Mol File:821794-92-7.mol
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Structure
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Chemical Properties
density 1.36
storage temp. Store at -20°C
solubility insoluble in H2O; ≥17.1 mg/mL in DMSO; ≥28.7 mg/mL in EtOH
form solid
color White to light yellow
InChIInChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)
InChIKeyIKLGYJACVCXYIL-UHFFFAOYSA-N
SMILESC(=O)(C1N(CCCO)C2C(C=1C1=CC=C(C)C=C1)=C(N)N=CN=2)CF
Safety Information
HS Code 2933998090
MSDS Information
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Usage And Synthesis
UsesFMK is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.
targetRSK1
IC 50RSK2
storageStore at -20°C
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Preparation Products And Raw materials
Tag:1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone(821794-92-7) Related Product Information