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| | 2-Amino-3-(trifluoromethyl)pyridine Basic information |
| | 2-Amino-3-(trifluoromethyl)pyridine Chemical Properties |
| Melting point | 70-72°C | | Boiling point | 203.2±35.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 4.18±0.36(Predicted) | | form | solid | | color | Off-white | | InChI | 1S/C6H5F3N2/c7-6(8,9)4-2-1-3-11-5(4)10/h1-3H,(H2,10,11) | | InChIKey | YWOWJQMFMXHLQD-UHFFFAOYSA-N | | SMILES | Nc1ncccc1C(F)(F)F | | CAS DataBase Reference | 183610-70-0(CAS DataBase Reference) |
| Hazard Codes | Xi,T | | Risk Statements | 25-36-43 | | Safety Statements | 26-36/37/39 | | RIDADR | 2811 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29333990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Skin Sens. 1 |
| | 2-Amino-3-(trifluoromethyl)pyridine Usage And Synthesis |
| Uses | 2-Amino-3-(trifluoromethyl)pyridine is a reagent used in the preparation of novel propanamide derivatives functioning as fatty acid amide inhibitors. | | Synthesis | The general procedure for the synthesis of 2-amino-3-trifluoromethylpyridine from 2-fluoro-3-trifluoromethylpyridine was as follows: 750 g of 2-fluoro-3-trifluoromethylpyridine and 700 g of water were added sequentially to an ammonia reactor, followed by the slow addition of 250 g of liquid ammonia. The reaction system was heated up to 130 °C, and the reaction pressure was maintained at a set value for 10 hours. Upon completion of the reaction, the system was cooled to 90 °C and the reaction mixture was transferred to a receiving kettle. After further cooling to 10 °C, the solid product was obtained by centrifugation and dried to obtain 2-amino-3-trifluoromethylpyridine in about 95% yield. | | References | [1] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017-0018; 0020-0021; 0023-0024 |
| | 2-Amino-3-(trifluoromethyl)pyridine Preparation Products And Raw materials |
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