2-Amino-3-(trifluoromethyl)pyridine

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2-Amino-3-(trifluoromethyl)pyridine manufacturers

2-Amino-3-(trifluoromethyl)pyridine Basic information

Product Name:	2-Amino-3-(trifluoromethyl)pyridine
Synonyms:	3-(TRIFLUOROMETHYL)-2-PYRIDINAMINE;3-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE;2-AMINO-3-(TRIFLUOROMETHYL)PYRIDINE;3-(Trifluoromethyl)pyridin-2-amine, 2-Amino-alpha,alpha,alpha-trifluoro-3-picoline;3-(TrifluoroMethyl)1-2-pyridinaMine;3-(TrifluoroMethyl)-2-pyridiMine;2-PyridinaMine, 3-(trifluoroMethyl)-;3-(Trifluoromethyl)-2-aminopyridine
CAS:	183610-70-0
MF:	C6H5F3N2
MW:	162.11
EINECS:	623-444-2
Product Categories:	Pyridines, Pyrimidines, Purines and Pteredines;Amines;Pyridines;Fluorine series;Amines and Anilines;Heterocycles
Mol File:	183610-70-0.mol

2-Amino-3-(trifluoromethyl)pyridine Chemical Properties

Melting point	70-72°C
Boiling point	203.2±35.0 °C(Predicted)
density	1.368±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	4.18±0.36(Predicted)
form	solid
color	Off-white
InChI	1S/C6H5F3N2/c7-6(8,9)4-2-1-3-11-5(4)10/h1-3H,(H2,10,11)
InChIKey	YWOWJQMFMXHLQD-UHFFFAOYSA-N
SMILES	Nc1ncccc1C(F)(F)F
CAS DataBase Reference	183610-70-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,T
Risk Statements	25-36-43
Safety Statements	26-36/37/39
RIDADR	2811
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	29333990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Irrit. 2 Skin Sens. 1

MSDS Information

2-Amino-3-(trifluoromethyl)pyridine Usage And Synthesis

Uses	2-Amino-3-(trifluoromethyl)pyridine is a reagent used in the preparation of novel propanamide derivatives functioning as fatty acid amide inhibitors.
Synthesis	65753-52-8 183610-70-0 The general procedure for the synthesis of 2-amino-3-trifluoromethylpyridine from 2-fluoro-3-trifluoromethylpyridine was as follows: 750 g of 2-fluoro-3-trifluoromethylpyridine and 700 g of water were added sequentially to an ammonia reactor, followed by the slow addition of 250 g of liquid ammonia. The reaction system was heated up to 130 °C, and the reaction pressure was maintained at a set value for 10 hours. Upon completion of the reaction, the system was cooled to 90 °C and the reaction mixture was transferred to a receiving kettle. After further cooling to 10 °C, the solid product was obtained by centrifugation and dried to obtain 2-amino-3-trifluoromethylpyridine in about 95% yield.
References	[1] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017-0018; 0020-0021; 0023-0024

2-Amino-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials	2-Pyridinamine, N-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)--->2-Fluoro-3-trifluoromethylpyridine-->Ammonia
Preparation Products	6-Chloro-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

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