2,5-Bis-Thiopheneboronic acid pinacol ester

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CAS:175361-81-6
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Products Intro: Product Name:2,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene
CAS:175361-81-6
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CAS:175361-81-6
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CAS:175361-81-6
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2,5-Bis-Thiopheneboronic acid pinacol ester manufacturers

2,5-Bis-Thiopheneboronic acid pinacol ester Basic information
Product Name:2,5-Bis-Thiopheneboronic acid pinacol ester
Synonyms:2,5-Bis-Thiopheneboronic acid pinacol ester;Thiophene-2,5-diboronic acid bis(pinacol) ester;2,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene;2,5-Thiophenediboronic acid bis(pinacol) ester;Bis(4,4,5,5-tetramethyl-1,3-dioxaborolane)-2,5-thiophene;Thiophene-2,5-diboronic acids pinacol ester;Thiophene-2,5-diboronic acid bis(pinacol) ester 99% (GC);2,2'-(2,5-Thiophenediyl)bis[4,4,5,5-tetramethyl-1,3,2-dioxaborolane]
CAS:175361-81-6
MF:C16H26B2O4S
MW:336.06
EINECS:
Product Categories:Thiophene (TH);Organoborons;Thiophene
Mol File:175361-81-6.mol
2,5-Bis-Thiopheneboronic acid pinacol ester Structure
2,5-Bis-Thiopheneboronic acid pinacol ester Chemical Properties
Melting point 216-220℃
Boiling point 434.3±30.0 °C(Predicted)
density 1.08±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form powder
color White to Almost white
InChIInChI=1S/C16H26B2O4S/c1-13(2)14(3,4)20-17(19-13)11-9-10-12(23-11)18-21-15(5,6)16(7,8)22-18/h9-10H,1-8H3
InChIKeyAOJXAKMKFDBHHT-UHFFFAOYSA-N
SMILESC1(B2OC(C)(C)C(C)(C)O2)SC(B2OC(C)(C)C(C)(C)O2)=CC=1
Safety Information
WGK Germany 3
HS Code 2934999090
Storage Class11 - Combustible Solids
Hazard ClassificationsAquatic Chronic 4
MSDS Information
2,5-Bis-Thiopheneboronic acid pinacol ester Usage And Synthesis
UsesDiboronic acid ester thiophene monomer for polymerization by Suzuki coupling; used for OPV and OFET applications.
Synthesis
2,5-Dibromothiophene

3141-27-3

Pinacol

76-09-5

Tributyl borate

688-74-4

2,5-Bis-Thiopheneboronic acid pinacol ester

175361-81-6

To a solution of 2,5-dibromothiophene (2.0 g, 8.3 mmol) in anhydrous THF (40 mL) was slowly added n-butyllithium (n-BuLi, 15 mL, 1.6 M hexanes solution, 25 mmol) dropwise at -78 °C and the reaction mixture was stirred for 1 hour keeping the temperature at -78 °C. Subsequently, tributyl borate (6.4 mL, 25 mmol) was added to the reaction mixture at the same temperature and the reaction system was gradually warmed to room temperature. After continued stirring for 2 hours, pinacol (3.8 g, 33 mmol) and acetic acid (1.4 mL, 25 mmol) were added sequentially and the resulting mixture was stirred and reacted for 14 hours at room temperature. After completion of the reaction, the reaction solution was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue (brown solid) was purified by recrystallization from a solvent mixture of ethyl acetate and hexane to afford the target product dipinacol ester of thiophene-2,5-diboronic acid (2.0 g, 75% yield) as a white solid.

References[1] Chem, 2016, vol. 1, # 1, p. 91 - 101
2,5-Bis-Thiopheneboronic acid pinacol ester Preparation Products And Raw materials
Raw materials2,5-Dibromothiophene-->Thiophene(SIV) (9CI)-->Pinacolborane-->Pinacol-->Tributyl borate-->boranylbis(propan-2-yl)amine-->n-Butyllithium-->Tetrahydrofuran-->Hexane-->Acetic acid
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