2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester

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2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester manufacturers

  • NG-497
  • NG-497 pictures
  • $59.00
  • 2026-07-27
  • CAS:2598242-66-9
  • Purity: 99.85%
  • Supply Ability: 10g
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester Basic information
Product Name:2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester
Synonyms:2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester;NG-497;NG-497, 10 mM in DMSO
CAS:2598242-66-9
MF:C18H21NO4
MW:315.36
EINECS:
Product Categories:
Mol File:2598242-66-9.mol
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester Structure
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester Chemical Properties
Boiling point 464.9±45.0 °C(Predicted)
density 1.111±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: insol,DMSO: 3 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
form A crystalline solid
pka2.93±0.26(Predicted)
color Off-white to light yellow
InChI1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3
InChIKeyVYEIBLWRGBQRPI-UHFFFAOYSA-N
SMILESO=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C
Safety Information
WGK Germany WGK 3
Storage Class10 - Combustible liquids
MSDS Information
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester Usage And Synthesis
UsesNG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research[1].
Biological ActivityNG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μM, Ki = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouse, rat, goat, pig, dog, marmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes), but not in HepG2 th at lacks ATGL hydrolase activity.
References[1] Gernot F Grabner, et al. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022 Apr 13;144(14):6237-6250. DOI:10.1021/jacs.1c10836
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester Preparation Products And Raw materials
Tag:2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester(2598242-66-9) Related Product Information
6-(3-Benzyloxyphenyl)picolinic acid 5-(3-Methoxy-phenyl)-1H-pyrrole-2-carboxylic acid 2-Pyridinecarboxylic acid, 6-(phenoxymethyl)-, ethyl ester 2-Pyridinecarboxylic acid, 4-methoxy-6-[4-(1-methylethoxy)phenyl]-, methyl ester 4-Ethoxy-2-pyridinecarboxylic acid ethyl ester 2-Pyridinecarboxylic acid, 6-(hydroxymethyl)-4-(phenylmethoxy)-, ethyl ester