- Oxetan-3-ol
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- $0.00 / 1g
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2026-02-02
- CAS:7748-36-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 2000tons
- Oxetan-3-ol
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- $0.10 / 1KG
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2025-12-24
- CAS:7748-36-9
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000 tons
- Oxetan-3-ol
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- $30.00 / 1KG
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2025-06-27
- CAS:7748-36-9
- Min. Order: 50KG
- Purity: 99%
- Supply Ability: 500000kg
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| | Oxetan-3-ol Basic information |
| | Oxetan-3-ol Chemical Properties |
| Boiling point | 153℃ | | density | 1.167 | | refractive index | 1.438 | | Fp | 87°(189°F) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Soluble), Methanol (Slightly) | | pka | 13.68±0.20(Predicted) | | form | Liquid | | color | Clear colorless | | InChI | InChI=1S/C3H6O2/c4-3-1-5-2-3/h3-4H,1-2H2 | | InChIKey | QMLWSAXEQSBAAQ-UHFFFAOYSA-N | | SMILES | O1CC(O)C1 |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | TSCA | No | | HS Code | 29329990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | Oxetan-3-ol Usage And Synthesis |
| Chemical Properties | Colorless Transparent Liquid | | Uses | 3-Oxetanol is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors. | | Synthesis | General procedure for the synthesis of oxetan-3-ol from 3-(phenylmethoxy)oxetane: 3-(phenylmethoxy)oxetane (59 g, 0.41 mol) and 10% palladium/carbon catalyst were added to methanol (1000 mL) in an autoclave. The hydrogenation reaction was completed by reacting under hydrogen atmosphere (10 atm) at 40°C for 24 hours. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration, followed by concentration under reduced pressure to remove the solvent. The colorless liquid product oxetan-3-ol (142.63 g) was obtained by distillation in 95.84% yield. | | References | [1] Patent: CN103554064, 2016, B. Location in patent: Paragraph 0031; 0032; 0041; 0042 |
| | Oxetan-3-ol Preparation Products And Raw materials |
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