| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:trans-3'-Hydroxy Cotinine
CAS:34834-67-8
Package:100Mg,10Mg
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| Company Name: |
Chemsky（shanghai）International Co.,Ltd.
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:trans-3'-Hydroxy Cotinine (1.0 Mg/ML in Methanol)
CAS:34834-67-8
Purity:98%
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| Company Name: |
Cato Research Chemicals Inc.
|
| Tel: |
020-81960175 |
| Email: |
min.he@cato-chem.com |
| Products Intro: |
Product Name:trans-3'-Hydroxy Cotinine
CAS:34834-67-8
Purity:95% Package:25Mg, 50Mg
|
- Hydroxycotinine
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- $483.00 / 5mg
-
2026-01-05
- CAS:34834-67-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Basic information |
| | 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Chemical Properties |
| Melting point | 107-109°C | | Boiling point | 416.5±45.0 °C(Predicted) | | density | 1.275±0.06 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml | | pka | 13.02±0.40(Predicted) | | form | A crystalline solid | | color | White to off-white | | Major Application | cell analysis
clinical research
general analytical
life science and biopharma
metabolomics | | InChI | InChI=1S/C10H12N2O2/c1-12-8(5-9(13)10(12)14)7-3-2-4-11-6-7/h2-4,6,8-9,13H,5H2,1H3/t8-,9+/m0/s1 | | InChIKey | XOKCJXZZNAUIQN-DTWKUNHWSA-N | | SMILES | CN1[C@@H](C[C@@H](O)C1=O)C=2C=CC=NC2 |
| Hazard Codes | F,T | | Risk Statements | 11-23/24/25-39/23/24/25 | | Safety Statements | 16-36/37-45 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 1 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Usage And Synthesis |
| Description | trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine . Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours). The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity. This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation. | | Chemical Properties | Off-White to Pale-Yellow Solid | | Uses | A metabolite of Nicotine. Carcinogen. | | Uses | trans-3''-Hydroxy Cotinine is a metabolite of Nicotine (N412450, (S)-(-)-Nicotine). | | Definition | ChEBI: An N-alkylpyrrolidine that is cotinine substituted at position C-3 by a hydroxy group (the 3R,5S-diastereomer). | | General Description | Trans-3′-Hydroxycotinine is a major nicotine metabolite excreted in the urine of smokers and users of other tobacco or nicotine products including cigars, chewing tobacco and snuff. This Certified Spiking Solution is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS. | | References | [1] ANDY Z X ZHU. Variation in trans-3’-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.[J]. PLoS ONE, 2013: e70938. DOI: 10.1371/journal.pone.0070938
[2] LINDA B VON WEYMARN S E M Cassandra Retzlaff. CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5’(1’)iminium ion.[J]. Journal of Pharmacology and Experimental Therapeutics, 2012, 343 2: 307-315. DOI: 10.1124/jpet.112.195255
[3] SHARON E MURPHY. Cotinine and trans 3′-hydroxycotinine in dried blood spots as biomarkers of tobacco exposure and nicotine metabolism[J]. Journal of Exposure Science and Environmental Epidemiology, 2013, 23 5: 513-518. DOI: 10.1038/jes.2013.7 |
| | 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Preparation Products And Raw materials |
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