2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-

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2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Suppliers list
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2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- manufacturers

  • GEM144
  • GEM144 pictures
  • $378.00
  • 2026-05-11
  • CAS:2487526-28-1
  • Purity: 98.10%
  • Supply Ability: 10g
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Basic information
Product Name:2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-
Synonyms:2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-;GEM144
CAS:2487526-28-1
MF:C28H31NO5
MW:461.55
EINECS:
Product Categories:
Mol File:2487526-28-1.mol
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Structure
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Chemical Properties
density 1.281±0.06 g/cm3(Predicted)
pka4.49±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Usage And Synthesis
UsesGEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts[1].
in vivo

GEM144 (50 mg/kg; p.o., bid, 5 days a week, for 3-4 weeks) significantly reduces tumor burden of MM487 with TGI of 72% in xenografts mice[1].

Animal Model:Female CD-1 nude mice (injected with MM473 and MM487)[1]
Dosage:50 mg/kg
Administration:PO, bid, 5 days a week, for 3-4 weeks
Result:Significantly reduced tumor burden of MM487 with TGI of 72%.
IC 50HDAC11: 8.23 μM (IC50)
References[1] Dallavalle S, et al. Antitumor activity of novel POLA1-HDAC11 dual inhibitors. Eur J Med Chem. 2022;228:113971. DOI:10.1016/j.ejmech.2021.113971
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Preparation Products And Raw materials
Tag:2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-(2487526-28-1) Related Product Information
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