Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- manufacturers
|
| | Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- Basic information |
| | Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- Chemical Properties |
| Boiling point | 617.9±65.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | pka | 8.01±0.10(Predicted) |
| | Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- Usage And Synthesis |
| Uses | Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128μg/mL in Caco-2 and Vero cell lines[1]. | | References | [1] Dokla EME, et al. Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. Eur J Med Chem. 2020;186:111850. DOI:10.1016/j.ejmech.2019.111850 |
| | Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- Preparation Products And Raw materials |
|