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| | 4-Quinolinol,3-amino-(6CI,9CI) Basic information |
| | 4-Quinolinol,3-amino-(6CI,9CI) Chemical Properties |
| Boiling point | 348.4±27.0 °C(Predicted) | | density | 1.363±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.35±0.50(Predicted) |
| | 4-Quinolinol,3-amino-(6CI,9CI) Usage And Synthesis |
| Synthesis | a) Synthesis of 3-aminoquinolin-4-ol
In a 100 mL round bottom flask, 4-hydroxy-3-nitroquinoline (500 mg, 2.629 mmol) was dissolved in methanol (50 mL) and 10% palladium/activated carbon catalyst (1.2 g, 10 wt%) was added. The reaction mixture was stirred at room temperature and under hydrogen atmosphere for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, and the filtrate was concentrated under reduced pressure to give the brown liquid-like product 3-aminoquinolin-4-ol (445 mg, quantitative yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 300 MHz): δ= 11.50 (br s, 1H), 8.09 (d, J = 8.4 Hz, 1H), 7.48 (s, 1H), 7.47 (m, 2H), 7.14-7.20 (m, 1H), 4.38 (br s, 2H). | | References | [1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 34-35
[2] Organic and Biomolecular Chemistry, 2013, vol. 11, # 7, p. 1179 - 1198
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 365,370
[4] Gazzetta Chimica Italiana, 1937, vol. 67, p. 222,229 |
| | 4-Quinolinol,3-amino-(6CI,9CI) Preparation Products And Raw materials |
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